Reactome | IDUA hydrolyses the unsulfated alpha-L-iduronosidic link in DS

Schema > Reaction > Entries

IDUA hydrolyses the unsulfated alpha-L-iduronosidic link in DS Show undefined attributes

catalystActivity	[CatalystActivity:10158127] L-iduronidase activity of IDUA [lysosomal lumen]
category	transition
compartment	[Compartment:161320] lysosomal lumen
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10158338
displayName	IDUA hydrolyses the unsulfated alpha-L-iduronosidic link in DS
eventOf	[Pathway:R-RNO-2024101] CS/DS degradation - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:21608] dermatan sulfate proteoglycan catabolic process
inferredFrom	[Reaction:R-HSA-1793186] IDUA hydrolyses the unsulfated alpha-L-iduronosidic link in DS - Homo sapiens
input	[SimpleEntity:R-ALL-1605715] H2O [lysosomal lumen] [SimpleEntity:R-ALL-2105025] IdoA-GalNAc(4S)-GlcA-Gal-Gal-Xyl [lysosomal lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	IDUA hydrolyses the unsulfated alpha-L-iduronosidic link in DS
output	[SimpleEntity:R-ALL-1678617] aldehydo-L-iduronic acid [lysosomal lumen] [SimpleEntity:R-ALL-2104993] CHEBI:63868 chain [lysosomal lumen]
precedingEvent	[Reaction:R-RNO-2105001] HEXA cleaves the terminal GalNAc from DS - Rattus norvegicus [Reaction:R-RNO-9638075] HEXB cleaves the terminal GalNAc from DS - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-1793186
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-2024101] CS/DS degradation
(inferredTo)	[Reaction:R-HSA-1793186] IDUA hydrolyses the unsulfated alpha-L-iduronosidic link in DS

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