Reactome | Keratan sulfate degradation

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Keratan sulfate degradation Show undefined attributes

created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10224293
displayName	Keratan sulfate degradation
eventOf	[Pathway:R-RNO-1638074] Keratan sulfate/keratin metabolism - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:11234] keratan sulfate proteoglycan catabolic process
hasDiagram	false
hasEHLD	false
hasEvent	[BlackBoxEvent:R-RNO-2046239] Extracellular KSPG translocates to the lysosome for degradation - Rattus norvegicus [Reaction:R-RNO-1630304] GALNS oligomer hydrolyses sulfate from Gal6S in keratan sulfate - Rattus norvegicus [Reaction:R-RNO-1630306] GLB1 hydrolyses a glycosaminoglycan - Rattus norvegicus [Reaction:R-RNO-1638032] GNS:Ca2+ cleaves sulfate from GlcNAc-6-sulfate units of keratan sulfate - Rattus norvegicus [Reaction:R-RNO-1638053] HEXA cleaves the terminal GlcNAc from keratan sulfate - Rattus norvegicus [Reaction:R-RNO-9638078] HEXB cleaves the terminal GlcNAc from keratan sulfate - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-2022857] Keratan sulfate degradation - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Keratan sulfate degradation
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-2022857
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-1638074] Keratan sulfate/keratin metabolism
(inferredTo)	[Pathway:R-HSA-2022857] Keratan sulfate degradation

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