Reactome | GNS:Ca2+ cleaves sulfate from GlcNAc-6-sulfate units of keratan sulfate

Schema > Reaction > Entries

GNS:Ca2+ cleaves sulfate from GlcNAc-6-sulfate units of keratan sulfate Show undefined attributes

catalystActivity	[CatalystActivity:10157335] N-acetylglucosamine-6-sulfatase activity of GNS:Ca2+ [lysosomal lumen]
category	transition
compartment	[Compartment:161320] lysosomal lumen
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10157337
displayName	GNS:Ca2+ cleaves sulfate from GlcNAc-6-sulfate units of keratan sulfate
eventOf	[Pathway:R-RNO-2022857] Keratan sulfate degradation - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-9638078] HEXB cleaves the terminal GlcNAc from keratan sulfate - Rattus norvegicus [Reaction:R-RNO-1638053] HEXA cleaves the terminal GlcNAc from keratan sulfate - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-1638032] GNS:Ca2+ cleaves sulfate from GlcNAc-6-sulfate units of keratan sulfate - Homo sapiens
input	[SimpleEntity:R-ALL-2104995] GlcNAc(S)-Gal-GlcNAc(S)-Gal [lysosomal lumen] [SimpleEntity:R-ALL-1605715] H2O [lysosomal lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	GNS:Ca2+ cleaves sulfate from GlcNAc-6-sulfate units of keratan sulfate N-acetylglucosamine 6-sulfatase (GNS) hydrolyses 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of keratan sulfate
output	[SimpleEntity:R-ALL-2105012] GlcNAc-Gal-GlcNAc(S)-Gal [lysosomal lumen] [SimpleEntity:R-ALL-1606845] SO4(2-) [lysosomal lumen]
precedingEvent	[Reaction:R-RNO-1630306] GLB1 hydrolyses a glycosaminoglycan - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-1638032
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-2022857] Keratan sulfate degradation
(precedingEvent)	[Reaction:R-RNO-9638078] HEXB cleaves the terminal GlcNAc from keratan sulfate [Reaction:R-RNO-1638053] HEXA cleaves the terminal GlcNAc from keratan sulfate
(inferredTo)	[Reaction:R-HSA-1638032] GNS:Ca2+ cleaves sulfate from GlcNAc-6-sulfate units of keratan sulfate

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