Reactome | Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta

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Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta Show undefined attributes

catalystActivity	[CatalystActivity:10125170] protein serine/threonine kinase activity of WNT:FZD:LRP5/6:DVL:AXIN:GSK3B [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10125172
displayName	Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta
eventOf	[Pathway:R-RNO-4641262] Disassembly of the destruction complex and recruitment of AXIN to the membrane - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-201677] Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta - Homo sapiens
input	5 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-RNO-1504184] WNT:FZD:LRP5/6:DVL:AXIN:GSK3B [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta
output	5 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-RNO-1458897] WNT:FZD:p5S/T-LRP5/6:DVL:AXIN:GSK3B [plasma membrane]
precedingEvent	[Reaction:R-RNO-1504186] DVL recruits GSK3beta:AXIN1 to the receptor complex - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-201677
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-4641262] Disassembly of the destruction complex and recruitment of AXIN to the membrane
(inferredTo)	[Reaction:R-HSA-201677] Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta

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