Reactome | Assembly of the destruction complex

Schema > Reaction > Entries

Assembly of the destruction complex Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10122933
displayName	Assembly of the destruction complex
eventOf	[Pathway:R-RNO-195253] Degradation of beta-catenin by the destruction complex - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-5229343] AXIN is phosphorylated in the destruction complex - Rattus norvegicus
goBiologicalProcess	[GO_BiologicalProcess:8854798] beta-catenin destruction complex assembly
inferredFrom	[Reaction:R-HSA-195251] Assembly of the destruction complex - Homo sapiens
input	[EntityWithAccessionedSequence:R-RNO-1504189] Amer1 [cytosol] [EntityWithAccessionedSequence:R-RNO-5246690] Apc [cytosol] [EntityWithAccessionedSequence:R-RNO-195249] Axin1 [cytosol] [EntityWithAccessionedSequence:R-RNO-195263] CSNK1A1 [cytosol] [EntityWithAccessionedSequence:R-RNO-198619] Glycogen synthase kinase-3 beta [cytosol] [Complex:R-RNO-196206] PP2A [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Assembly of the destruction complex
output	[Complex:R-RNO-195250] AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-195251
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-195253] Degradation of beta-catenin by the destruction complex
(precedingEvent)	[Reaction:R-RNO-5229343] AXIN is phosphorylated in the destruction complex
(inferredTo)	[Reaction:R-HSA-195251] Assembly of the destruction complex