Reactome | CCNA:p-T160-CDK2 [nucleoplasm]

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CCNA:p-T160-CDK2 [nucleoplasm] Show undefined attributes

catalystActivities	[CatalystActivity:10103328] cyclin-dependent protein serine/threonine kinase activity of CCNA:p-T160-CDK2 [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-RNO-187944] CCNA:p-T160-CDK2:p-E2F1/p-E2F3 [nucleoplasm] - Rattus norvegicus [Complex:R-RNO-187932] CCNA:p-T160-CDK2:E2F1/E2F3 [nucleoplasm] - Rattus norvegicus
consumedByEvent	[Reaction:R-RNO-3788708] CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 - Rattus norvegicus [Reaction:R-RNO-187937] Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3 - Rattus norvegicus [Reaction:R-RNO-188371] Association of Cyclin A:Cdk2 with Cdh1 - Rattus norvegicus [Reaction:R-RNO-5684081] MRN complex binds CDK2 and RBBP8 - Rattus norvegicus
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10103327
displayName	CCNA:p-T160-CDK2 [nucleoplasm]
hasComponent	[CandidateSet:R-RNO-75202] CCNA [nucleoplasm] [EntityWithAccessionedSequence:R-RNO-187967] phospho-p-T160-CDK2 [nucleoplasm]
inDisease	false
inferredFrom	[Complex:R-HSA-187952] CCNA:p-T160-CDK2 [nucleoplasm] - Homo sapiens
maxDepth	3
memberOf	[DefinedSet:R-RNO-8848491] CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] - Rattus norvegicus [DefinedSet:R-RNO-4088020] CCNA:p-CDK1/2 [nucleoplasm] - Rattus norvegicus
name	CCNA:p-T160-CDK2
negativelyRegulates	[NegativeRegulation:10115723] Negative regulation by 'CCNA:p-T160-CDK2 [nucleoplasm]'
producedByEvent	[Reaction:R-RNO-187949] CAK-mediated phosphorylation of Cyclin A:Cdk2 - Rattus norvegicus [Reaction:R-RNO-5684096] CDK2 phosphorylates RBBP8 - Rattus norvegicus
schemaClass	Complex
species	[Species:48895] Rattus norvegicus
stId	R-RNO-187952
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Referrals

(input)	[Reaction:R-RNO-3788708] CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 [Reaction:R-RNO-187937] Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3 [Reaction:R-RNO-188371] Association of Cyclin A:Cdk2 with Cdh1 [Reaction:R-RNO-5684081] MRN complex binds CDK2 and RBBP8
(hasComponent)	[Complex:R-RNO-187944] CCNA:p-T160-CDK2:p-E2F1/p-E2F3 [nucleoplasm] [Complex:R-RNO-187932] CCNA:p-T160-CDK2:E2F1/E2F3 [nucleoplasm] [Complex:R-RNO-188387] Cyclin A:phospho-Cdk2(Thr 160):phospho-Cdh1:phospho-APC/C complex [nucleoplasm] [Complex:R-RNO-188374] Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm] [Complex:R-RNO-5684094] DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:CCNA:p-T160-CDK2:RBBP8 [nucleoplasm]
(output)	[Reaction:R-RNO-187949] CAK-mediated phosphorylation of Cyclin A:Cdk2 [Reaction:R-RNO-5684096] CDK2 phosphorylates RBBP8
(hasMember)	[DefinedSet:R-RNO-8848491] CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] [DefinedSet:R-RNO-4088020] CCNA:p-CDK1/2 [nucleoplasm]
(regulator)	[NegativeRegulation:10115723] Negative regulation by 'CCNA:p-T160-CDK2 [nucleoplasm]'
(physicalEntity)	[CatalystActivity:10103328] cyclin-dependent protein serine/threonine kinase activity of CCNA:p-T160-CDK2 [nucleoplasm]
(activeUnit)	[CatalystActivity:10183649] protein serine/threonine kinase activity of DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:CCNA:p-T160-CDK2:RBBP8 [nucleoplasm]
(inferredTo)	[Complex:R-HSA-187952] CCNA:p-T160-CDK2 [nucleoplasm]

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