Reactome | CDKN1A,CDKN1B [nucleoplasm]

Schema > DefinedSet > Entries

catalystActivities	[CatalystActivity:10103879] cyclin-dependent protein serine/threonine kinase inhibitor activity of CDKN1A,CDKN1B [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-RNO-187926] Cyclin A:Cdk2:p21/p27 complex [nucleoplasm] - Rattus norvegicus [Complex:R-RNO-68376] Cyclin E:CDK2:CDKN1A,CDKN1B [nucleoplasm] - Rattus norvegicus
consumedByEvent	[Reaction:R-RNO-187934] Inactivation of Cyclin A:Cdk2 complexes by p27/p21 - Rattus norvegicus [Reaction:R-RNO-69562] Inactivation of Cyclin E:Cdk2 complexes by p27/p21 - Rattus norvegicus
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10103876
displayName	CDKN1A,CDKN1B [nucleoplasm]
hasMember	[EntityWithAccessionedSequence:R-RNO-182585] CDKN1A [nucleoplasm] - Rattus norvegicus [EntityWithAccessionedSequence:R-RNO-182563] Cdkn1b [nucleoplasm] - Rattus norvegicus
inDisease	false
inferredFrom	[DefinedSet:R-HSA-182558] CDKN1A,CDKN1B [nucleoplasm] - Homo sapiens
maxDepth	2
name	CDKN1A,CDKN1B p21,p27
schemaClass	DefinedSet
species	[Species:48895] Rattus norvegicus
stId	R-RNO-182558

(input)	[Reaction:R-RNO-187934] Inactivation of Cyclin A:Cdk2 complexes by p27/p21 [Reaction:R-RNO-69562] Inactivation of Cyclin E:Cdk2 complexes by p27/p21
(hasComponent)	[Complex:R-RNO-187926] Cyclin A:Cdk2:p21/p27 complex [nucleoplasm] [Complex:R-RNO-68376] Cyclin E:CDK2:CDKN1A,CDKN1B [nucleoplasm] [Complex:R-RNO-187516] Cyclin E/A:p-T160-CDK2:CDKN1A,CDKN1B [nucleoplasm]
(physicalEntity)	[CatalystActivity:10103879] cyclin-dependent protein serine/threonine kinase inhibitor activity of CDKN1A,CDKN1B [nucleoplasm]
(inferredTo)	[DefinedSet:R-HSA-182558] CDKN1A,CDKN1B [nucleoplasm]