Reactome | APOE [extracellular region]

Schema > EntityWithAccessionedSequence > Entries

catalystActivities	[CatalystActivity:10166471] low-density lipoprotein particle receptor binding activity of APOE [extracellular region]
compartment	[Compartment:984] extracellular region
componentOf	[Complex:R-RNO-174792] chylomicron remnant:apoE complex [extracellular region] - Rattus norvegicus [Complex:R-RNO-2423794] CR:atREs:HSPG:apoE [plasma membrane] - Rattus norvegicus [Complex:R-RNO-174807] chylomicron remnant [extracellular region] - Rattus norvegicus [Complex:R-RNO-174643] spherical HDL:apoC-II:apoC-III:apoE [extracellular region] - Rattus norvegicus [Complex:R-RNO-2395771] mature CM:atREs [extracellular region] - Rattus norvegicus
consumedByEvent	[Reaction:R-RNO-174739] chylomicron remnant + apoE => chylomicron remnant:apoE complex - Rattus norvegicus [Reaction:R-RNO-2423785] CR:atREs binds apoE and HSPG - Rattus norvegicus [Reaction:R-RNO-266303] Spherical HDL binds C and E apolipoproteins - Rattus norvegicus
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10119409
displayName	APOE [extracellular region]
endCoordinate	317
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-174646] APOE [extracellular region] - Homo sapiens
maxDepth	1
memberOf	[DefinedSet:R-RNO-2173760] Ligands of MSR1 [extracellular region] - Rattus norvegicus
name	APOE P02650
referenceEntity	[ReferenceGeneProduct:uniprot:P02650] UniProt:P02650
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48895] Rattus norvegicus
stId	R-RNO-174646
startCoordinate	19

(input)	[Reaction:R-RNO-2423785] CR:atREs binds apoE and HSPG [Reaction:R-RNO-174739] chylomicron remnant + apoE => chylomicron remnant:apoE complex [Reaction:R-RNO-266303] Spherical HDL binds C and E apolipoproteins
(physicalEntity)	[CatalystActivity:10166471] low-density lipoprotein particle receptor binding activity of APOE [extracellular region]
(activeUnit)	[CatalystActivity:10166471] low-density lipoprotein particle receptor binding activity of APOE [extracellular region]
(hasComponent)	[Complex:R-RNO-2423794] CR:atREs:HSPG:apoE [plasma membrane] [Complex:R-RNO-2395771] mature CM:atREs [extracellular region] [Complex:R-RNO-174792] chylomicron remnant:apoE complex [extracellular region] [Complex:R-RNO-174807] chylomicron remnant [extracellular region] [Complex:R-RNO-174798] TG-depleted chylomicron [extracellular region] [Complex:R-RNO-174697] chylomicron [extracellular region] [Complex:R-RNO-174643] spherical HDL:apoC-II:apoC-III:apoE [extracellular region]
(hasMember)	[DefinedSet:R-RNO-2173760] Ligands of MSR1 [extracellular region]
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-174646] APOE [extracellular region]