Reactome | p-2S-SMAD2,3 [cytosol]

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-RNO-2187343] p-2S-SMAD2/3:PMEPA1 [early endosome membrane] - Rattus norvegicus [Complex:R-RNO-171180] TGFB1:p-TGFBR:ZFYVE9:p-2S-SMAD2,3 [early endosome membrane] - Rattus norvegicus
consumedByEvent	[Reaction:R-RNO-2187405] MTMR4 binds phosphorylated SMAD2/3 - Rattus norvegicus [Reaction:R-RNO-2187355] PMEPA1 sequesters phosphorylated SMAD2/3 - Rattus norvegicus [Reaction:R-RNO-170847] Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 - Rattus norvegicus [Reaction:R-RNO-170847] Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 - Rattus norvegicus [Reaction:R-RNO-170847] Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 - Rattus norvegicus
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10118013
displayName	p-2S-SMAD2,3 [cytosol]
hasMember	[EntityWithAccessionedSequence:R-RNO-3009186] phospho-p-S465,S467-SMAD2 [cytosol] - Rattus norvegicus [EntityWithAccessionedSequence:R-RNO-171184] phospho-p-S423,S425-SMAD3 [cytosol] - Rattus norvegicus
inDisease	false
inferredFrom	[DefinedSet:R-HSA-171182] p-2S-SMAD2,3 [cytosol] - Homo sapiens
maxDepth	2
name	p-2S-SMAD2,3 p-S465,467-SMAD2,p-S423,425-SMAD3 Phospho-R-SMAD
producedByEvent	[Reaction:R-RNO-1549526] Phosphorylation of SMAD2,3 by Activin:Activin Receptor - Rattus norvegicus [Reaction:R-RNO-170850] Phosphorylated SMAD2/3 dissociates from TGFBR - Rattus norvegicus
schemaClass	DefinedSet
species	[Species:48895] Rattus norvegicus
stId	R-RNO-171182

(input)	[Reaction:R-RNO-2187355] PMEPA1 sequesters phosphorylated SMAD2/3 [Reaction:R-RNO-2187405] MTMR4 binds phosphorylated SMAD2/3 [Reaction:R-RNO-170847] Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4
(hasComponent)	[Complex:R-RNO-2187343] p-2S-SMAD2/3:PMEPA1 [early endosome membrane] [Complex:R-RNO-2187399] p-2S-SMAD2/3:MTMR4 [early endosome membrane] [Complex:R-RNO-171180] TGFB1:p-TGFBR:ZFYVE9:p-2S-SMAD2,3 [early endosome membrane]
(output)	[Reaction:R-RNO-1549526] Phosphorylation of SMAD2,3 by Activin:Activin Receptor [Reaction:R-RNO-170850] Phosphorylated SMAD2/3 dissociates from TGFBR
(inferredTo)	[DefinedSet:R-HSA-171182] p-2S-SMAD2,3 [cytosol]