Reactome | MAPKs [cytosol]

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MAPKs [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-RNO-418179] F2R:ARRB2:MAPKs:SRC-1 [plasma membrane] - Rattus norvegicus [Complex:R-RNO-418103] F2R:ARRB1:MAPKs:SRC-1 [plasma membrane] - Rattus norvegicus [Complex:R-RNO-5674138] WDR83:LAMTOR2:LAMTOR3:activated RAF:MAP2K:MAPK complex [endosome membrane] - Rattus norvegicus
consumedByEvent	[BlackBoxEvent:R-RNO-1168459] Lyn activates ERK - Rattus norvegicus [BlackBoxEvent:R-RNO-9732753] JAK1-activated RAF1 phosphorylates MAPKs - Rattus norvegicus [Reaction:R-RNO-418170] F2R:ARRB1 binds MAPKs, SRC-1 - Rattus norvegicus [Reaction:R-RNO-418176] F2R:ARRB2 binds MAPKs, SRC-1 - Rattus norvegicus [Reaction:R-RNO-5674366] IL17RD binds p-2S MAP2Ks and MAPKs - Rattus norvegicus [Reaction:R-RNO-5674132] WDR83:LAMTOR2:LAMTOR3 binds MAPK components - Rattus norvegicus [Reaction:R-RNO-9610152] Activated BRAF recruits MAP2Ks and MAPKs to the endosome - Rattus norvegicus [Reaction:R-RNO-5672972] MAP2Ks and MAPKs bind to the activated RAF complex - Rattus norvegicus
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10136564
displayName	MAPKs [cytosol]
hasMember	[EntityWithAccessionedSequence:R-RNO-59282] MAPK1 [cytosol] - Rattus norvegicus [EntityWithAccessionedSequence:R-RNO-59284] MAPK3 [cytosol] - Rattus norvegicus
inDisease	false
inferredFrom	[DefinedSet:R-HSA-169291] MAPKs [cytosol] - Homo sapiens
maxDepth	2
memberOf	[DefinedSet:R-RNO-5675361] MAPK monomers and dimers [cytosol] - Rattus norvegicus
name	MAPKs MAPK1,MAPK3
schemaClass	DefinedSet
species	[Species:48895] Rattus norvegicus
stId	R-RNO-169291

Referrals

(input)	[BlackBoxEvent:R-RNO-1168459] Lyn activates ERK [Reaction:R-RNO-418170] F2R:ARRB1 binds MAPKs, SRC-1 [Reaction:R-RNO-418176] F2R:ARRB2 binds MAPKs, SRC-1 [Reaction:R-RNO-5674366] IL17RD binds p-2S MAP2Ks and MAPKs [Reaction:R-RNO-5674132] WDR83:LAMTOR2:LAMTOR3 binds MAPK components [BlackBoxEvent:R-RNO-9732753] JAK1-activated RAF1 phosphorylates MAPKs [Reaction:R-RNO-9610152] Activated BRAF recruits MAP2Ks and MAPKs to the endosome [Reaction:R-RNO-5672972] MAP2Ks and MAPKs bind to the activated RAF complex
(hasComponent)	[Complex:R-RNO-418103] F2R:ARRB1:MAPKs:SRC-1 [plasma membrane] [Complex:R-RNO-418179] F2R:ARRB2:MAPKs:SRC-1 [plasma membrane] [Complex:R-RNO-5674360] IL17RD:p-2S MAP2Ks:MAPKs [Golgi membrane] [Complex:R-RNO-5674138] WDR83:LAMTOR2:LAMTOR3:activated RAF:MAP2K:MAPK complex [endosome membrane] [Complex:R-RNO-9610134] RAP1:GTP:activated BRAF dimer:MAPK2K:MAPK complex [endosome membrane] [Complex:R-RNO-9610136] RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:MAPK complex [endosome membrane] [Complex:R-RNO-5672720] activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] [Complex:R-RNO-5672723] activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane]
(hasMember)	[DefinedSet:R-RNO-5675361] MAPK monomers and dimers [cytosol]
(inferredTo)	[DefinedSet:R-HSA-169291] MAPKs [cytosol]

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