Reactome | Collagen biosynthesis and modifying enzymes

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Collagen biosynthesis and modifying enzymes Show undefined attributes

created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10224357
displayName	Collagen biosynthesis and modifying enzymes
eventOf	[Pathway:R-RNO-1474290] Collagen formation - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:20746] collagen fibril organization
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-RNO-2002460] P4HB binds Collagen chains - Rattus norvegicus [Reaction:R-RNO-1980233] Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen - Rattus norvegicus [Reaction:R-RNO-1981104] Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines - Rattus norvegicus [Reaction:R-RNO-1981120] Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2 - Rattus norvegicus [Reaction:R-RNO-1981128] Galactosylation of collagen propeptide hydroxylysines by PLOD3 - Rattus norvegicus [Reaction:R-RNO-1981157] Glucosylation of collagen propeptide hydroxylysines - Rattus norvegicus [Pathway:R-RNO-8948216] Collagen chain trimerization - Rattus norvegicus [Reaction:R-RNO-2022073] Procollagen triple helix formation - Rattus norvegicus [BlackBoxEvent:R-RNO-2089971] Secretion of collagens - Rattus norvegicus [BlackBoxEvent:R-RNO-2152276] Secretion of transmembrane collagens - Rattus norvegicus [Reaction:R-RNO-2002428] Removal of fibrillar collagen N-propeptides - Rattus norvegicus [Reaction:R-RNO-2002440] Removal of fibrillar collagen C-propeptides - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-1650814] Collagen biosynthesis and modifying enzymes - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	Collagen biosynthesis and modifying enzymes
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-1650814
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-1474290] Collagen formation
(inferredTo)	[Pathway:R-HSA-1650814] Collagen biosynthesis and modifying enzymes

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