Reactome | kallikrein binds SERPING1

Schema > Reaction > Entries

kallikrein binds SERPING1 Show undefined attributes

category	binding
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10114879
displayName	kallikrein binds SERPING1
eventOf	[Pathway:R-RNO-9855719] Regulation of FXIIa and plasma kallikrein activity - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:1221431] negative regulation of blood coagulation, intrinsic pathway
inferredFrom	[Reaction:R-HSA-158399] kallikrein binds SERPING1 - Homo sapiens
input	[Complex:R-RNO-158140] Plasma kallikrein [extracellular region] [EntityWithAccessionedSequence:R-RNO-158296] Serping1 [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	kallikrein binds SERPING1 kallikrein + C1Inh -> kallikrein:C1Inh
output	[Complex:R-RNO-158423] kallikrein:C1Inh [extracellular region]
precedingEvent	[BlackBoxEvent:R-RNO-9650473] SERPING1 is secreted - Rattus norvegicus [Reaction:R-RNO-9938539] kallikrein:kininogen:cell surface receptor -> kallikrein + cleaved kininogen:cell surface receptor + bradykinin - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-158399
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-9855719] Regulation of FXIIa and plasma kallikrein activity
(inferredTo)	[Reaction:R-HSA-158399] kallikrein binds SERPING1