Reactome | Plasma kallikrein [extracellular region]

Schema > Complex > Entries

catalystActivities	[CatalystActivity:10220734] serine-type endopeptidase activity of Plasma kallikrein [extracellular region]
compartment	[Compartment:984] extracellular region
componentOf	[Complex:R-RNO-158334] kallikrein:alpha2-macroglobulin [extracellular region] - Rattus norvegicus
consumedByEvent	[Reaction:R-RNO-158340] kallikrein + alpha2-macroglobulin -> kallikrein:alpha2-macrogloulin - Rattus norvegicus [Reaction:R-RNO-158399] kallikrein binds SERPING1 - Rattus norvegicus
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10114856
displayName	Plasma kallikrein [extracellular region]
hasComponent	[EntityWithAccessionedSequence:R-RNO-158239] Klkb1 [extracellular region] [EntityWithAccessionedSequence:R-RNO-158181] Klkb1 [extracellular region]
inDisease	false
inferredFrom	[Complex:R-HSA-158140] Plasma kallikrein [extracellular region] - Homo sapiens
maxDepth	2
memberOf	[DefinedSet:R-RNO-1602468] proMMP1 initial activators [extracellular region] - Rattus norvegicus
name	Plasma kallikrein
producedByEvent	[Reaction:R-RNO-9938539] kallikrein:kininogen:cell surface receptor -> kallikrein + cleaved kininogen:cell surface receptor + bradykinin - Rattus norvegicus
schemaClass	Complex
species	[Species:48895] Rattus norvegicus
stId	R-RNO-158140
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(physicalEntity)	[CatalystActivity:10220734] serine-type endopeptidase activity of Plasma kallikrein [extracellular region]
(hasMember)	[DefinedSet:R-RNO-1602468] proMMP1 initial activators [extracellular region] [DefinedSet:R-RNO-1604721] proMMP3 initial activators [extracellular region]
(hasComponent)	[Complex:R-RNO-158334] kallikrein:alpha2-macroglobulin [extracellular region] [Complex:R-RNO-158423] kallikrein:C1Inh [extracellular region]
(input)	[Reaction:R-RNO-158340] kallikrein + alpha2-macroglobulin -> kallikrein:alpha2-macrogloulin [Reaction:R-RNO-158399] kallikrein binds SERPING1
(inferredTo)	[Complex:R-HSA-158140] Plasma kallikrein [extracellular region]
(output)	[Reaction:R-RNO-9938539] kallikrein:kininogen:cell surface receptor -> kallikrein + cleaved kininogen:cell surface receptor + bradykinin