Reactome | HNP1-4 are stored in primary neutrophil granules

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HNP1-4 are stored in primary neutrophil granules Show undefined attributes

category	transition
compartment	[Compartment:1470028] azurophil granule lumen [Compartment:17963] Golgi lumen
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10154578
displayName	HNP1-4 are stored in primary neutrophil granules
eventOf	[Pathway:R-RNO-1462054] Alpha-defensins - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-1462041] HNP1-4 are released into phagocytic vacuoles - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-1462003] HNP1-4 are stored in primary neutrophil granules - Homo sapiens
input	[CandidateSet:R-RNO-1470042] Defensins alpha 1-4 [Golgi lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	HNP1-4 are stored in primary neutrophil granules
output	[CandidateSet:R-RNO-1470049] Defensins alpha 1-4 [azurophil granule lumen]
precedingEvent	[Reaction:R-RNO-1462039] Pro-HNP1-4 are cleaved to biologically active defensin - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-1462003
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-1462054] Alpha-defensins
(precedingEvent)	[Reaction:R-RNO-1462041] HNP1-4 are released into phagocytic vacuoles
(inferredTo)	[Reaction:R-HSA-1462003] HNP1-4 are stored in primary neutrophil granules

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