Reactome | Hbegf [extracellular region]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:984] extracellular region
componentOf	[Complex:R-RNO-8857547] HBEGF:EGFR [plasma membrane] - Rattus norvegicus
consumedByEvent	[BlackBoxEvent:R-RNO-2179387] Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor - Rattus norvegicus
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10120217
displayName	Hbegf [extracellular region]
endCoordinate	148
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-1233234] HBEGF(63-148) [extracellular region] - Homo sapiens
maxDepth	1
memberOf	[DefinedSet:R-RNO-1233230] EGF-like ligands [extracellular region] - Rattus norvegicus [DefinedSet:R-RNO-9624194] EGF-like ligands [extracellular region] - Rattus norvegicus
name	Hbegf HBEGF(63-148) Q06175
producedByEvent	[Reaction:R-RNO-9624272] MMPs cleave HB-EGF - Rattus norvegicus
referenceEntity	[ReferenceGeneProduct:uniprot:Q06175] UniProt:Q06175
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48895] Rattus norvegicus
stId	R-RNO-1233234
startCoordinate	63

(output)	[Reaction:R-RNO-9624272] MMPs cleave HB-EGF
(hasComponent)	[Complex:R-RNO-8857547] HBEGF:EGFR [plasma membrane] [Complex:R-RNO-2179388] HB-EGF:p-6Y-EGFR [plasma membrane]
(input)	[BlackBoxEvent:R-RNO-2179387] Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor
(hasMember)	[DefinedSet:R-RNO-9624194] EGF-like ligands [extracellular region] [DefinedSet:R-RNO-1233230] EGF-like ligands [extracellular region]
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-1233234] HBEGF(63-148) [extracellular region]

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