Reactome | GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol]

Schema > Complex > Entries

compartment	[Compartment:70101] cytosol
consumedByEvent	[Reaction:R-RNO-109823] MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 - Rattus norvegicus
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10108601
displayName	GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol]
hasComponent	[Complex:R-RNO-109797] GRB2-1:SOS1 [cytosol] [DefinedSet:R-RNO-112322] p-Y-IRS1,p-Y-IRS2 [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-109800] GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] - Homo sapiens
maxDepth	3
memberOf	[DefinedSet:R-RNO-5672601] RAS GEFs [plasma membrane] - Rattus norvegicus
name	GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2
producedByEvent	[Reaction:R-RNO-74736] GRB2-1:SOS1 binds p-IRS1,p-IRS2 - Rattus norvegicus
schemaClass	Complex
species	[Species:48895] Rattus norvegicus
stId	R-RNO-109800
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(output)	[Reaction:R-RNO-74736] GRB2-1:SOS1 binds p-IRS1,p-IRS2
(input)	[Reaction:R-RNO-109823] MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2
(hasMember)	[DefinedSet:R-RNO-5672601] RAS GEFs [plasma membrane]
(inferredTo)	[Complex:R-HSA-109800] GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol]

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