Reactome | MyD88 dependent cascade initiated on endosome

Schema > Pathway > Entries

compartment	[Compartment:70101] cytosol [Compartment:74700] endosome membrane [Compartment:7660] nucleoplasm
created	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
dbId	11128704
displayName	MyD88 dependent cascade initiated on endosome
eventOf	[Pathway:R-PFA-168181] Toll Like Receptor 7/8 (TLR7/8) Cascade - Plasmodium falciparum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-PFA-975138] TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation - Plasmodium falciparum
inferredFrom	[Pathway:R-HSA-975155] MyD88 dependent cascade initiated on endosome - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	5
name	MyD88 dependent cascade initiated on endosome
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:170928] Plasmodium falciparum
stId	R-PFA-975155
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-PFA-168181] Toll Like Receptor 7/8 (TLR7/8) Cascade [Pathway:R-PFA-168138] Toll Like Receptor 9 (TLR9) Cascade
(hasEncapsulatedEvent)	[Pathway:R-PFA-5686938] Regulation of TLR by endogenous ligand
(inferredTo)	[Pathway:R-HSA-975155] MyD88 dependent cascade initiated on endosome

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