Reactome | RAB5 GEFs exchange GTP for GDP on RAB5

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RAB5 GEFs exchange GTP for GDP on RAB5 Show undefined attributes

catalystActivity	[CatalystActivity:11124997] guanyl-nucleotide exchange factor activity of RAB5 GEFs [cytosol]
category	transition
compartment	[Compartment:171062] early endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
dbId	11124999
displayName	RAB5 GEFs exchange GTP for GDP on RAB5
eventOf	[Pathway:R-PFA-8876198] RAB GEFs exchange GTP for GDP on RABs - Plasmodium falciparum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-8875320] RAB5 GEFs exchange GTP for GDP on RAB5 - Homo sapiens
input	[Complex:R-PFA-8875330] GGC-RAB5:GDP:GDIs,CHMs [cytosol] [SimpleEntity:R-ALL-29438] GTP [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	RAB5 GEFs exchange GTP for GDP on RAB5
output	[DefinedSet:R-PFA-8875305] GDIs,CHMs [cytosol] [SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-PFA-8875316] GGC-RAB5:GTP [early endosome membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:170928] Plasmodium falciparum
stId	R-PFA-8875320
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-PFA-8876198] RAB GEFs exchange GTP for GDP on RABs
(inferredTo)	[Reaction:R-HSA-8875320] RAB5 GEFs exchange GTP for GDP on RAB5

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