Reactome | DNA ligase I ligates single stranded nick in double stranded DNA

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DNA ligase I ligates single stranded nick in double stranded DNA Show undefined attributes

catalystActivity	[CatalystActivity:11109318] DNA ligase activity of LIG1 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
dbId	11118389
displayName	DNA ligase I ligates single stranded nick in double stranded DNA
eventOf	[Pathway:R-PFA-5358606] Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) - Plasmodium falciparum [Pathway:R-PFA-5358565] Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) - Plasmodium falciparum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-5358592] DNA ligase I ligates single stranded nick in double stranded DNA - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [OtherEntity:R-ALL-5358610] DNA containing single strand nick (5' phosphate, 3' hydroxyl) [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	DNA ligase I ligates single stranded nick in double stranded DNA
output	[SimpleEntity:R-ALL-164121] AMP [nucleoplasm] [SimpleEntity:R-ALL-113541] PPi [nucleoplasm] [OtherEntity:R-ALL-109966] Repaired double-stranded DNA [nucleoplasm]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:170928] Plasmodium falciparum
stId	R-PFA-5358592
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-PFA-5358606] Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) [Pathway:R-PFA-5358565] Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
(inferredTo)	[Reaction:R-HSA-5358592] DNA ligase I ligates single stranded nick in double stranded DNA

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