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Entries
DNA ligase I ligates single stranded nick in double stranded DNA
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authored
[InstanceEdit:5358529] May, B, 2014-03-28
catalystActivity
[CatalystActivity:5690630] DNA ligase activity of LIG1 [nucleoplasm]
category
transition
compartment
[Compartment:7660] nucleoplasm
created
[InstanceEdit:5358539] May, Bruce, 2014-03-30
dbId
5358592
displayName
DNA ligase I ligates single stranded nick in double stranded DNA
edited
[InstanceEdit:5358529] May, B, 2014-03-28
eventOf
[Pathway:R-HSA-5358606] Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) - Homo sapiens
[Pathway:R-HSA-5358565] Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) - Homo sapiens
input
[SimpleEntity:R-ALL-29358] ATP [nucleoplasm]
[OtherEntity:R-ALL-5358610] DNA containing single strand nick (5' phosphate, 3' hydroxyl) [nucleoplasm]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:5358604] Reconstitution of 5'-directed human mismatch repair in a purified system
[LiteratureReference:5358580] Human mismatch repair: reconstitution of a nick-directed bidirectional reaction
[LiteratureReference:5358862] Kinetic mechanism of human DNA ligase I reveals magnesium-dependent changes in the rate-limiting step that compromise ligation efficiency
[LiteratureReference:5358863] DNA ligases: structure, reaction mechanism, and function
[LiteratureReference:5358900] Purification and properties of two DNA ligases from human placenta
[LiteratureReference:5358885] Differential recruitment of DNA Ligase I and III to DNA repair sites
[LiteratureReference:5358859] Mechanism underlying replication protein a stimulation of DNA ligase I
modified
[InstanceEdit:10931649] Wright, Adam, 2024-03-08
name
DNA ligase I ligates single stranded nick in double stranded DNA
orthologousEvent
[Reaction:R-PFA-5358592] DNA ligase I ligates single stranded nick in double stranded DNA - Plasmodium falciparum
[Reaction:R-SCE-5358592] DNA ligase I ligates single stranded nick in double stranded DNA - Saccharomyces cerevisiae
[Reaction:R-SPO-5358592] DNA ligase I ligates single stranded nick in double stranded DNA - Schizosaccharomyces pombe
[Reaction:R-DDI-5358592] DNA ligase I ligates single stranded nick in double stranded DNA - Dictyostelium discoideum
[Reaction:R-CEL-5358592] DNA ligase I ligates single stranded nick in double stranded DNA - Caenorhabditis elegans
[Reaction:R-DME-5358592] DNA ligase I ligates single stranded nick in double stranded DNA - Drosophila melanogaster
[Reaction:R-GGA-5358592] DNA ligase I ligates single stranded nick in double stranded DNA - Gallus gallus
[Reaction:R-SSC-5358592] DNA ligase I ligates single stranded nick in double stranded DNA - Sus scrofa
[Reaction:R-BTA-5358592] DNA ligase I ligates single stranded nick in double stranded DNA - Bos taurus
[Reaction:R-CFA-5358592] DNA ligase I ligates single stranded nick in double stranded DNA - Canis familiaris
[Reaction:R-RNO-5358592] DNA ligase I ligates single stranded nick in double stranded DNA - Rattus norvegicus
[Reaction:R-MMU-5358592] DNA ligase I ligates single stranded nick in double stranded DNA - Mus musculus
output
[SimpleEntity:R-ALL-164121] AMP [nucleoplasm]
[SimpleEntity:R-ALL-113541] PPi [nucleoplasm]
[OtherEntity:R-ALL-109966] Repaired double-stranded DNA [nucleoplasm]
precedingEvent
[Reaction:R-HSA-5358579] DNA polymerase delta polymerizes DNA across single stranded gap - Homo sapiens
releaseDate
2014-06-10
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:5566522] Edelbrock, Michael A, 2014-05-23
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-5358592
summation
[Summation:5358851] LIG1 (DNA ligase I) catalyzes the formation of a phosphodies...
Referrals
(hasEvent)
[Pathway:R-HSA-5358606] Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
[Pathway:R-HSA-5358565] Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
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