Reactome | Reuptake of serotonin from the synapse

Schema > Reaction > Entries

Reuptake of serotonin from the synapse Show undefined attributes

catalystActivity	[CatalystActivity:11113323] monoamine transmembrane transporter activity of SLC6A4 [plasma membrane]
category	transition
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
dbId	11113325
displayName	Reuptake of serotonin from the synapse
eventOf	[Pathway:R-PFA-442660] SLC-mediated transport of neurotransmitters - Plasmodium falciparum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-380620] Reuptake of serotonin from the synapse - Homo sapiens
input	[SimpleEntity:R-ALL-114523] 5HT [extracellular region] [SimpleEntity:R-ALL-74113] Na+ [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	Reuptake of serotonin from the synapse
output	[SimpleEntity:R-ALL-209914] 5HT [cytosol] [SimpleEntity:R-ALL-83910] Na+ [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:170928] Plasmodium falciparum
stId	R-PFA-380620
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-PFA-442660] SLC-mediated transport of neurotransmitters
(inferredTo)	[Reaction:R-HSA-380620] Reuptake of serotonin from the synapse

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