Reactome | SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane

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SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane Show undefined attributes

catalystActivity	[CatalystActivity:11111800] adenine transmembrane transporter activity of SLC25A5,6 dimers [mitochondrial inner membrane]
category	transition
compartment	[Compartment:70616] mitochondrial inner membrane
created	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
dbId	11111802
displayName	SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane
eventOf	[Pathway:R-PFA-83936] Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane - Plasmodium falciparum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-163215] SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane - Homo sapiens
input	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-113593] ATP [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane ADP-ATP translocase maintains a high ADP:ATP ratio in the matrix
output	[SimpleEntity:R-ALL-113581] ADP [mitochondrial matrix] [SimpleEntity:R-ALL-113592] ATP [cytosol]
precedingEvent	[Reaction:R-PFA-74220] (d)AMP + ATP <=> (d)ADP + ADP (AK1) - Plasmodium falciparum
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:170928] Plasmodium falciparum
stId	R-PFA-163215
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-PFA-83936] Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane
(inferredTo)	[Reaction:R-HSA-163215] SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane

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