Reactome | cAMP induces dissociation of inactive PKA tetramers

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cAMP induces dissociation of inactive PKA tetramers Show undefined attributes

catalystActivity	[CatalystActivity:11111469] cAMP binding activity of PKA tetramer:4xcAMP [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
dbId	11111471
displayName	cAMP induces dissociation of inactive PKA tetramers
eventOf	[Pathway:R-PFA-164378] PKA activation in glucagon signalling - Plasmodium falciparum [Pathway:R-PFA-432040] Vasopressin regulates renal water homeostasis via Aquaporins - Plasmodium falciparum [Pathway:R-PFA-9856530] High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells - Plasmodium falciparum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-PFA-432232] Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) - Plasmodium falciparum [Reaction:R-PFA-9861318] PKA phosphorylates NOS3 (eNOS) on serine-633 - Plasmodium falciparum
inferredFrom	[Reaction:R-HSA-111925] cAMP induces dissociation of inactive PKA tetramers - Homo sapiens
input	[Complex:R-PFA-8951729] PKA tetramer:4xcAMP [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	cAMP induces dissociation of inactive PKA tetramers
output	[Complex:R-PFA-111923] cAMP:PKA regulatory subunit [cytosol] 2 × [DefinedSet:R-PFA-57844-4] Homologues of PRKACA [cytosol]
precedingEvent	[Reaction:R-PFA-8951727] cAMP binds PKA tetramer - Plasmodium falciparum
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:170928] Plasmodium falciparum
stId	R-PFA-111925
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-PFA-164378] PKA activation in glucagon signalling [Pathway:R-PFA-432040] Vasopressin regulates renal water homeostasis via Aquaporins [Pathway:R-PFA-9856530] High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells [Pathway:R-PFA-9634597] GPER1 signaling [Pathway:R-PFA-442720] CREB1 phosphorylation through the activation of Adenylate Cyclase [Pathway:R-PFA-180024] DARPP-32 events [Pathway:R-PFA-163615] PKA activation
(precedingEvent)	[Reaction:R-PFA-432232] Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA) [Reaction:R-PFA-9861318] PKA phosphorylates NOS3 (eNOS) on serine-633
(inferredTo)	[Reaction:R-HSA-111925] cAMP induces dissociation of inactive PKA tetramers