Reactome | MAPK1 phosphorylates Rps6ka1

Schema > Reaction > Entries

authored	[InstanceEdit:9624342] Orlic-Milacic, Marija, 2018-10-10
catalystActivity	[CatalystActivity:9619970] protein serine/threonine kinase activity of p-T185,Y187 MAPK1 dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9619971] Orlic-Milacic, Marija, 2018-09-19
dbId	9619973
displayName	MAPK1 phosphorylates Rps6ka1
edited	[InstanceEdit:9628239] Orlic-Milacic, Marija, 2018-11-07
input	3 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [EntityWithAccessionedSequence:R-RNO-444983] Rps6ka1 [cytosol]
isChimeric	true
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9619976] Identification of regulatory phosphorylation sites in mitogen-activated protein kinase (MAPK)-activated protein kinase-1a/p90rsk that are inducible by MAPK
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	MAPK1 phosphorylates Rps6ka1
orthologousEvent	[Reaction:R-HSA-9619843] ERKs phosphorylate RSKs - Homo sapiens
output	3 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [EntityWithAccessionedSequence:R-RNO-9619966] p-T359,S363,T573-Rps6ka1 [cytosol]
releaseDate	2018-12-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9627687] Yi, Feng, 2018-11-02 [InstanceEdit:9628437] Hansen, Kasper B, 2018-11-02
schemaClass	Reaction
species	[Species:48887] Homo sapiens [Species:48895] Rattus norvegicus
stId	R-NUL-9619973
summation	[Summation:9619972] Recombinant human MAPK1 (ERK2) phosphorylates recombinant ra...

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