Reactome | AMPK-negatively regulates binding of MAPT to microtubules

Schema > Reaction > Entries

authored	[InstanceEdit:9624342] Orlic-Milacic, Marija, 2018-10-10
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9619540] Orlic-Milacic, Marija, 2018-09-17
dbId	9619539
displayName	AMPK-negatively regulates binding of MAPT to microtubules
edited	[InstanceEdit:9628239] Orlic-Milacic, Marija, 2018-11-07
input	[EntityWithAccessionedSequence:R-HSA-9619519] MAPT-8 [cytosol] [Complex:R-BTA-9619688] Microtubule [cytosol]
isChimeric	true
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9619528] AMP-activated protein kinase (AMPK) is a tau kinase, activated in response to amyloid ?-peptide exposure
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	AMPK-negatively regulates binding of MAPT to microtubules
orthologousEvent	[Reaction:R-HSA-9619542] AMPK negatively regulates binding of MAPT to microtubules - Homo sapiens
output	[Complex:R-NUL-9619748] MAPT-8:Microtubule [cytosol]
regulatedBy	[NegativeRegulation:9619746] Negative regulation by 'p-T183-AMPKalpha1beta1gamma1 [cytosol]'
releaseDate	2018-12-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9627687] Yi, Feng, 2018-11-02 [InstanceEdit:9628437] Hansen, Kasper B, 2018-11-02
schemaClass	Reaction
species	[Species:48898] Bos taurus [Species:48887] Homo sapiens [Species:48895] Rattus norvegicus
stId	R-NUL-9619539
summation	[Summation:9619541] Phosphorylation of recombinant human MAPT (Tau) by recombina...

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