AMPK-negatively regulates binding of MAPT to microtubules

Stable Identifier
R-NUL-9619539
Type
Reaction [binding]
Species
Bos taurus
Compartment
cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
AMPK-negatively regulates binding of MAPT to microtubules
Phosphorylation of recombinant human MAPT (Tau) by recombinant rat AMPK complex negatively regulates binding of recombinant human MAPT to bovine microtubules (Thornton et al. 2011).
Literature References
PubMed ID Title Journal Year
21204788 AMP-activated protein kinase (AMPK) is a tau kinase, activated in response to amyloid β-peptide exposure

Muckett, PJ, Sastre, M, Carling, D, Bright, NJ, Thornton, C

Biochem. J. 2011
Participants
Input
Output
This event is regulated
Negatively by
Regulator
p-T183-AMPKalpha1beta1gamma1 [cytosol] (Rattus norvegicus)
Orthologous Events
AMPK negatively regulates binding of MAPT to microtubules (Homo sapiens)
Authored
Orlic-Milacic, M  (2018-10-10)
Reviewed
Hansen, KB  (2018-11-02)
Yi, F  (2018-11-02)
Created
Orlic-Milacic, M  (2018-09-18)
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