Reactome | Wnt5a/11b bind Ca2+ Fzd receptors

Schema > Reaction > Entries

Wnt5a/11b bind Ca2+ Fzd receptors Show undefined attributes

authored	[InstanceEdit:3858502] Rothfels, K, 2013-07-09
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:3965439] Rothfels, K, 2013-07-23
dbId	3965440
displayName	Wnt5a/11b bind Ca2+ Fzd receptors
edited	[InstanceEdit:4663813] Matthews, L, 2013-10-07
input	[DefinedSet:R-NUL-3965379] WNT/Ca2+ Fzds [plasma membrane] [DefinedSet:R-XLA-3965376] Wnt5a/Wnt11 [extracellular region]
isChimeric	true
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3965295] Ca(2+)/calmodulin-dependent protein kinase II is stimulated by Wnt and Frizzled homologs and promotes ventral cell fates in Xenopus [LiteratureReference:3965336] Wnt5a signaling directly affects cell motility and invasion of metastatic melanoma [LiteratureReference:3965318] The Wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation [LiteratureReference:3965333] Wnt5A/CaMKII signaling contributes to the inflammatory response of macrophages and is a target for the antiinflammatory action of activated protein C and interleukin-10 [LiteratureReference:3965328] Wnt-5a/Ca2+-induced NFAT activity is counteracted by Wnt-5a/Yes-Cdc42-casein kinase 1alpha signaling in human mammary epithelial cells [LiteratureReference:3965321] The Wnt5A/protein kinase C pathway mediates motility in melanoma cells via the inhibition of metastasis suppressors and initiation of an epithelial to mesenchymal transition
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Wnt5a/11b bind Ca2+ Fzd receptors
orthologousEvent	[Reaction:R-HSA-3965446] WNT5A and WNT11 bind FZD receptors to initiate Ca2+ signaling - Homo sapiens
output	[Complex:R-NUL-3965388] Wnt5a/Wnt11:Fzd receptors [plasma membrane]
releaseDate	2013-12-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5099870] Kikuchi, Akira, 2013-11-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens [Species:48892] Mus musculus [Species:48895] Rattus norvegicus [Species:51320] Xenopus laevis
stId	R-NUL-3965440
summation	[Summation:3965350] Stimulation of intracellular calcium release has been demons...