Reactome | EXTL3 dimer transfers GlcNAc to the GAG linker

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EXTL3 dimer transfers GlcNAc to the GAG linker Show undefined attributes

catalystActivity	[CatalystActivity:10097975] glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity of EXTL2,3 [Golgi membrane]
category	transition
compartment	[Compartment:20699] Golgi membrane [Compartment:17963] Golgi lumen
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10097977
displayName	EXTL3 dimer transfers GlcNAc to the GAG linker
eventOf	[Pathway:R-MMU-2022928] HS-GAG biosynthesis - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-2022856] EXT1:EXT2 transfers GlcA to heparan - Mus musculus
goBiologicalProcess	[GO_BiologicalProcess:19668] heparan sulfate proteoglycan biosynthetic process
inferredFrom	[Reaction:R-HSA-9953259] EXTL3 dimer transfers GlcNAc to the GAG linker - Homo sapiens
input	[DefinedSet:R-MMU-2076551] GlcA-Gal-Gal-Xyl-HS proteins [Golgi lumen] [SimpleEntity:R-ALL-914003] UDP-GlcNAc [Golgi lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	EXTL3 dimer transfers GlcNAc to the GAG linker The addition of GlcNAc to the terminal glucuronate residue starts heparan polymerization
output	[SimpleEntity:R-ALL-425969] H+ [Golgi lumen] [DefinedSet:R-MMU-2076465] Heparan-PGs [Golgi lumen] [SimpleEntity:R-ALL-205687] UDP [Golgi lumen]
precedingEvent	[Reaction:R-MMU-1889955] B3GAT dimers transfer GlcA to tetrasaccharide linker - Mus musculus [Reaction:R-MMU-744231] SLC35D2 exchanges UDP-GlcNAc for UMP - Mus musculus [Reaction:R-MMU-741450] SLC35A3 exchanges UDP-GlcNAc for UMP - Mus musculus [Reaction:R-MMU-742354] SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-9953259
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-2022928] HS-GAG biosynthesis
(precedingEvent)	[Reaction:R-MMU-2022856] EXT1:EXT2 transfers GlcA to heparan
(inferredTo)	[Reaction:R-HSA-9953259] EXTL3 dimer transfers GlcNAc to the GAG linker

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