Reactome | HS-GAG biosynthesis

Schema > Pathway > Entries

HS-GAG biosynthesis Show undefined attributes

created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10100453
displayName	HS-GAG biosynthesis
eventOf	[Pathway:R-MMU-1638091] Heparan sulfate/heparin (HS-GAG) metabolism - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:19668] heparan sulfate proteoglycan biosynthetic process
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-MMU-744231] SLC35D2 exchanges UDP-GlcNAc for UMP - Mus musculus [Reaction:R-MMU-9953259] EXTL3 dimer transfers GlcNAc to the GAG linker - Mus musculus [Reaction:R-MMU-2022856] EXT1:EXT2 transfers GlcA to heparan - Mus musculus [Reaction:R-MMU-2022851] EXT1:EXT2 transfers GlcNAc to the heparan chain - Mus musculus [Reaction:R-MMU-2076392] EXT1:EXT2 transfers GlcA to heparan - Mus musculus [Reaction:R-MMU-2022887] NDST1-4 N-deacetylates GlcNAc residues in heparan - Mus musculus [Reaction:R-MMU-2022860] NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) - Mus musculus [Reaction:R-MMU-2076508] HS2ST1 trimer sulfates IdoA at C2 in heparan sulfate - Mus musculus [Reaction:R-MMU-2076611] HS3ST2-6 sulfate GlcN at C3 in heparan sulfate - Mus musculus [Reaction:R-MMU-2076383] HS3ST1 sulfates GlcN at C3 in heparan sulfate - Mus musculus [Reaction:R-MMU-2076419] HS6STs sulfate GlcN at C6 in heparan sulfate/heparin - Mus musculus [BlackBoxEvent:R-MMU-2024108] Some HSPGs are secreted to the plasma membrane - Mus musculus
inferredFrom	[Pathway:R-HSA-2022928] HS-GAG biosynthesis - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	HS-GAG biosynthesis
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-2022928
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-1638091] Heparan sulfate/heparin (HS-GAG) metabolism
(hasEncapsulatedEvent)	[Pathway:R-MMU-2024096] HS-GAG degradation [Pathway:R-MMU-1971475] Glycosaminoglycan-protein linkage region biosynthesis
(inferredTo)	[Pathway:R-HSA-2022928] HS-GAG biosynthesis

© 2026 Reactome

Cite Us!