Reactome | FXI:kininogen + GPIb:IX:V -> FXI:kininogen:GPIb:IX:V

Schema > Reaction > Entries

FXI:kininogen + GPIb:IX:V -> FXI:kininogen:GPIb:IX:V Show undefined attributes

category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10097339
displayName	FXI:kininogen + GPIb:IX:V -> FXI:kininogen:GPIb:IX:V
eventOf	[Pathway:R-MMU-9935598] FXIIa, PKa-dependent activation of coagulation pathway - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-9936430] factor XI:kininogen:GPIb:IX:V complex -> factor XIa:kininogen:GPIb:IX:V complex (XIIa catalyst) - Mus musculus
inferredFrom	[Reaction:R-HSA-9936451] FXI:kininogen + GPIb:IX:V -> FXI:kininogen:GPIb:IX:V - Homo sapiens
input	[Complex:R-MMU-9936459] factor XI:kininogen [extracellular region] [Complex:R-MMU-114668] GPIb-IX-V [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	FXI:kininogen + GPIb:IX:V -> FXI:kininogen:GPIb:IX:V FXI:kininogen binds GPIb:IX:V
output	[Complex:R-MMU-9936436] FXI:KNG1:GPIb:IX:V [plasma membrane]
precedingEvent	[Reaction:R-MMU-9936440] FXI + kininogen -> FXI:kininogen - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-9936451
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-9935598] FXIIa, PKa-dependent activation of coagulation pathway
(precedingEvent)	[Reaction:R-MMU-9936430] factor XI:kininogen:GPIb:IX:V complex -> factor XIa:kininogen:GPIb:IX:V complex (XIIa catalyst)
(inferredTo)	[Reaction:R-HSA-9936451] FXI:kininogen + GPIb:IX:V -> FXI:kininogen:GPIb:IX:V

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