Reactome | FXIIa, PKa-dependent activation of coagulation pathway

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FXIIa, PKa-dependent activation of coagulation pathway Show undefined attributes

created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10099145
displayName	FXIIa, PKa-dependent activation of coagulation pathway
eventOf	[Pathway:R-MMU-9769739] Regulation of clotting cascade - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-MMU-158300] factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst) - Mus musculus [Reaction:R-MMU-9936440] FXI + kininogen -> FXI:kininogen - Mus musculus [Reaction:R-MMU-9936451] FXI:kininogen + GPIb:IX:V -> FXI:kininogen:GPIb:IX:V - Mus musculus [Reaction:R-MMU-9936430] factor XI:kininogen:GPIb:IX:V complex -> factor XIa:kininogen:GPIb:IX:V complex (XIIa catalyst) - Mus musculus [Reaction:R-MMU-9936467] factor IX -> factor IXa + factor IX activation peptide (kallikrein catalyst) - Mus musculus
inferredFrom	[Pathway:R-HSA-9935598] FXIIa, PKa-dependent activation of coagulation pathway - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	FXIIa, PKa-dependent activation of coagulation pathway FXIIa, PKa activate coagulation factors
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-9935598
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-9769739] Regulation of clotting cascade
(inferredTo)	[Pathway:R-HSA-9935598] FXIIa, PKa-dependent activation of coagulation pathway

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