Reactome | Rora,b,c positivley regulates and Nr1d1 (Rev-erba) negatively regulates expression of Bmal1 (Arntl)

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Rora,b,c positivley regulates and Nr1d1 (Rev-erba) negatively regulates expression of Bmal1 (Arntl) Show undefined attributes

authored	[InstanceEdit:9911300] May, Bruce, 2024-05-28
category	omitted
compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol
created	[InstanceEdit:9911579] May, Bruce, 2024-06-01
dbId	9911570
displayName	Rora,b,c positivley regulates and Nr1d1 (Rev-erba) negatively regulates expression of Bmal1 (Arntl)
edited	[InstanceEdit:9911300] May, Bruce, 2024-05-28
input	[EntityWithAccessionedSequence:R-MMU-5663253] Arntl gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:508721] Differential control of Bmal1 circadian transcription by REV-ERB and ROR nuclear receptors [LiteratureReference:879761] The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator [LiteratureReference:549400] The orphan nuclear receptor Rev-erbalpha recruits the N-CoR/histone deacetylase 3 corepressor to regulate the circadian Bmal1 gene [LiteratureReference:508661] Bidirectional role of orphan nuclear receptor RORalpha in clock gene transcriptions demonstrated by a novel reporter assay system [LiteratureReference:508641] The orphan nuclear receptor RORalpha regulates circadian transcription of the mammalian core-clock Bmal1 [LiteratureReference:549438] A functional genomics strategy reveals Rora as a component of the mammalian circadian clock [LiteratureReference:879778] A transcription factor response element for gene expression during circadian night [LiteratureReference:9911573] ROR? directly regulates the circadian expression of clock genes and downstream targets in vivo [LiteratureReference:1368121] Transcriptional coactivator PGC-1alpha integrates the mammalian clock and energy metabolism [LiteratureReference:1368104] RORalpha regulates the expression of genes involved in lipid homeostasis in skeletal muscle cells: caveolin-3 and CPT-1 are direct targets of ROR
maxDepth	1
modified	[InstanceEdit:9938697] May, Bruce, 2025-02-18
name	Rora,b,c positivley regulates and Nr1d1 (Rev-erba) negatively regulates expression of Bmal1 (Arntl)
orthologousEvent	[BlackBoxEvent:R-HSA-9911580] RORA,B,C positively regulates expression and NR1D1 (REV-ERBA) negatively regulates expression of BMAL1 (ARNTL) - Homo sapiens
output	[EntityWithAccessionedSequence:R-MMU-508660] Arntl [cytosol]
previousReviewStatus	[ReviewStatus:9821383] three stars
regulatedBy	[NegativeGeneExpressionRegulation:R-MMU-549585] Negative gene expression regulation by 'Nr1d1:heme:Corepressors:Arntl gene [nucleoplasm]' [PositiveGeneExpressionRegulation:9911574] Positive gene expression regulation by 'Rora,b,c:Coactivator:Arntl gene (update) [nucleoplasm]' [PositiveGeneExpressionRegulation:9931507] Positive gene expression regulation by 'Sirt1 [nucleoplasm]'
regulationReference	[RegulationReference:9642686] Negative regulation by 'Nr1d1:heme:Corepressors:Arntl gene [nucleoplasm]' The orphan nuclear receptor Rev-erbalpha recruits the N-CoR/histone deacetylase 3 corepressor to regulate the circadian Bmal1 gene [RegulationReference:9911578] Positive gene expression regulation by 'Rora,b,c:Coactivator:Arntl gene (update) [nucleoplasm]' Bidirectional role of orphan nuclear receptor RORalpha in clock gene transcriptions demonstrated by a novel reporter assay system [RegulationReference:9931526] Positive gene expression regulation by 'Sirt1 [nucleoplasm]' SIRT1 mediates central circadian control in the SCN by a mechanism that decays with aging
releaseDate	2025-03-26
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9938389] Sancar, Aziz, 2025-02-14 [InstanceEdit:9938694] Albrecht, Urs, 2025-02-18
schemaClass	BlackBoxEvent
species	[Species:48892] Mus musculus
stId	R-MMU-9911570
summation	[Summation:9911568] Rora, Rorb, or Rorc bind ROR responsive elements (RREs, RORE...

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