Reactome | Phosphorylated Bmal1:Clock,Npas2 and coactivators positively regulate expression of Period-1 (Per1)

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Phosphorylated Bmal1:Clock,Npas2 and coactivators positively regulate expression of Period-1 (Per1) Show undefined attributes

authored	[InstanceEdit:9909554] May, Bruce, 2024-05-14
category	omitted
compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol
created	[InstanceEdit:9909554] May, Bruce, 2024-05-14
dbId	9909564
deleted	[Deleted:9939501] Deletion of instance: 549491 [Deleted:9032447] Deletion of instance: 1368110 [Deleted:9032440] Deletion of instance: 5334727
displayName	Phosphorylated Bmal1:Clock,Npas2 and coactivators positively regulate expression of Period-1 (Per1)
edited	[InstanceEdit:9909554] May, Bruce, 2024-05-14
input	[EntityWithAccessionedSequence:R-MMU-5663163] Per1 gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:421313] CK2alpha phosphorylates BMAL1 to regulate the mammalian clock [LiteratureReference:400260] Cryptochromes impair phosphorylation of transcriptional activators in the clock: a general mechanism for circadian repression [LiteratureReference:549441] The human and mouse Period1 genes: five well-conserved E-boxes additively contribute to the enhancement of mPer1 transcription [LiteratureReference:549404] Genome-wide expression analysis of mouse liver reveals CLOCK-regulated circadian output genes [LiteratureReference:549497] Rhythmic histone acetylation underlies transcription in the mammalian circadian clock [LiteratureReference:549485] Dual role of the CLOCK/BMAL1 circadian complex in transcriptional regulation [LiteratureReference:549407] Two period homologs: circadian expression and photic regulation in the suprachiasmatic nuclei [LiteratureReference:879763] RIGUI, a putative mammalian ortholog of the Drosophila period gene [LiteratureReference:879742] A differential response of two putative mammalian circadian regulators, mper1 and mper2, to light [LiteratureReference:9909537] DNA binding, but not interaction with Bmal1, is responsible for DEC1-mediated transcription regulation of the circadian gene mPer1 [LiteratureReference:9911256] Inactivation of Cipc alters the expression of Per1 but not circadian rhythms in mice [LiteratureReference:9926652] Chronobiological analysis of circadian patterns in transcription of seven key clock genes in six peripheral tissues in mice [LiteratureReference:9929313] Identification of functional clock-controlled elements involved in differential timing of Per1 and Per2 transcription [LiteratureReference:9909376] Bimodal regulation of mPeriod promoters by CREB-dependent signaling and CLOCK/BMAL1 activity [LiteratureReference:879713] Circadian oscillation of a mammalian homologue of the Drosophila period gene [LiteratureReference:9929261] A light-independent oscillatory gene mPer3 in mouse SCN and OVLT [LiteratureReference:9933420] Changes in pH and NADPH regulate the DNA binding activity of neuronal PAS domain protein 2, a mammalian circadian transcription factor [LiteratureReference:879766] NPAS2: an analog of clock operative in the mammalian forebrain
maxDepth	1
modified	[InstanceEdit:9938697] May, Bruce, 2025-02-18
name	Phosphorylated Bmal1:Clock,Npas2 and coactivators positively regulate expression of Period-1 (Per1)
orthologousEvent	[BlackBoxEvent:R-HSA-9909561] Phosphorylated BMAL1:CLOCK,NPAS2 and coactivators positively regulate expression of Period-1 (PER1) - Homo sapiens
output	[EntityWithAccessionedSequence:R-MMU-508663] Per1 [cytosol]
previousReviewStatus	[ReviewStatus:9821383] three stars
regulatedBy	[NegativeGeneExpressionRegulation:9909569] Negative gene expression regulation by 'Bhlhe40 dimer [nucleoplasm]' [NegativeGeneExpressionRegulation:9911278] Negative gene expression regulation by 'Cipc:p-S-Clock:p-S-Bmal1 [nucleoplasm]' [PositiveGeneExpressionRegulation:9926585] Positive gene expression regulation by 'p-S97-Bmal1:p-T451,T461-Clock,p-Npas2:Crebbp:Kmt2a:Per1 gene [nucleoplasm]'
regulationReference	[RegulationReference:9909563] Negative gene expression regulation by 'Bhlhe40 dimer [nucleoplasm]' DNA binding, but not interaction with Bmal1, is responsible for DEC1-mediated transcription regulation of the circadian gene mPer1 [RegulationReference:9911250] Negative gene expression regulation by 'Cipc:p-S-Clock:p-S-Bmal1 [nucleoplasm]' CIPC is a mammalian circadian clock protein without invertebrate homologues [RegulationReference:9926609] Positive gene expression regulation by 'p-S97-Bmal1:p-T451,T461-Clock,p-Npas2:Crebbp:Kmt2a:Per1 gene [nucleoplasm]' CK2alpha phosphorylates BMAL1 to regulate the mammalian clock
releaseDate	2025-03-26
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9938389] Sancar, Aziz, 2025-02-14 [InstanceEdit:9938694] Albrecht, Urs, 2025-02-18
schemaClass	BlackBoxEvent
species	[Species:48892] Mus musculus
stId	R-MMU-9909564
summation	[Summation:9929316] Phosphorylated Bmal1:Clock heterodimers bind five E-boxes (H... [Summation:9910804] Dec1 (Bhlhe40) negatively regulates transcription of Per1 by... [Summation:9911252] In the nucleus, Cipc binds Clock in the Clock:Bmal1 complex ...

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