Reactome | Phosphorylation of PDPK1 on serine-241

Schema > BlackBoxEvent > Entries

Phosphorylation of PDPK1 on serine-241 Show undefined attributes

category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10095578
displayName	Phosphorylation of PDPK1 on serine-241
eventOf	[Pathway:R-MMU-9856530] High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-9860785] PDPK1 (PDK1) phosphorylates PKN2 on threonine-816 - Mus musculus
inferredFrom	[BlackBoxEvent:R-HSA-9860796] Phosphorylation of PDPK1 on serine-241 - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [EntityWithAccessionedSequence:R-MMU-202210] PDPK1 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Phosphorylation of PDPK1 on serine-241
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [EntityWithAccessionedSequence:R-MMU-9860799] phospho-p-S241-PDPK1 [cytosol]
precedingEvent	[Reaction:R-MMU-9860787] P2RY2 binds ATP - Mus musculus
regulatedBy	[PositiveRegulation:10095579] Positive regulation by 'G-protein alpha (q/11) [plasma membrane]' [PositiveRegulation:10095580] Positive regulation by 'P2RY2:ATP [plasma membrane]' [PositiveRegulation:R-HSA-2744259] Positive regulation by 'Ca2+ [cytosol]'
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:48892] Mus musculus
stId	R-MMU-9860796
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-9856530] High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
(precedingEvent)	[Reaction:R-MMU-9860785] PDPK1 (PDK1) phosphorylates PKN2 on threonine-816
(inferredTo)	[BlackBoxEvent:R-HSA-9860796] Phosphorylation of PDPK1 on serine-241