Reactome | High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells

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High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Show undefined attributes

created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10098965
displayName	High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
eventOf	[Pathway:R-MMU-9860931] Response of endothelial cells to shear stress - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:8857185] vascular endothelial cell response to laminar fluid shear stress
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-MMU-9865670] TRPV4 tetramer binds CALM1:Ca2+ (calmodulin:Ca2+) - Mus musculus [Reaction:R-MMU-9861511] Ca2+ activates Calpain2 (m-Calpain) - Mus musculus [Reaction:R-MMU-9861485] Calpain2 (m-Calpain, CAPN2:CAPNS:Ca2+) cleaves VCL (Vinculin) - Mus musculus [Reaction:R-MMU-9860787] P2RY2 binds ATP - Mus musculus [BlackBoxEvent:R-MMU-9860796] Phosphorylation of PDPK1 on serine-241 - Mus musculus [Reaction:R-MMU-9860785] PDPK1 (PDK1) phosphorylates PKN2 on threonine-816 - Mus musculus [Reaction:R-MMU-9860800] mTORC2 phosphorylates AKT1 on serine-473 - Mus musculus [Reaction:R-MMU-9860759] p-T816-PKN2 phosphorylates AKT1 on serine-308 - Mus musculus [Reaction:R-MMU-9860792] Phospho-AKT1 phosphorylates NOS3 (eNOS) on serine-1177 - Mus musculus [Reaction:R-MMU-9860808] p-T816-PKN2 phosphorylates NOS3 (eNOS) on serine-1179 - Mus musculus [BlackBoxEvent:R-MMU-9861331] Secretion of ADM (Adrenomedullin) - Mus musculus [Reaction:R-MMU-9861332] ADM (Adrenomedullin) binds CALCRL:RAMP2 - Mus musculus [Reaction:R-MMU-9861324] ADM:CALCRL:RAMP2:G-alpha(s):GDP:G-beta:G-gamma exchanges GDP for GTP - Mus musculus [Reaction:R-MMU-8951727] cAMP binds PKA tetramer - Mus musculus [Reaction:R-MMU-111925] cAMP induces dissociation of inactive PKA tetramers - Mus musculus [Reaction:R-MMU-9861318] PKA phosphorylates NOS3 (eNOS) on serine-633 - Mus musculus
inferredFrom	[Pathway:R-HSA-9856530] High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-9856530
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-9860931] Response of endothelial cells to shear stress
(inferredTo)	[Pathway:R-HSA-9856530] High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells

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