Reactome | Pparg binds Ebf2-bound gene loci

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Pparg binds Ebf2-bound gene loci Show undefined attributes

authored	[InstanceEdit:9844988] Orlic-Milacic, Marija, 2023-09-25
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9844689] Orlic-Milacic, Marija, 2023-09-21
dbId	9844700
displayName	Pparg binds Ebf2-bound gene loci
edited	[InstanceEdit:9855181] Orlic-Milacic, Marija, 2023-11-29
input	10 × [CandidateSet:R-MMU-9854724] Brown,beige aipocyte-specific coactivators of Pparg:Rxra [nucleoplasm] [CandidateSet:R-MMU-9854717] Ebf2, Ebf2:Blnc1 lncRNA:Hnrnpu:Ppara gene, Prdm16 gene, Ucp1 gene, (Cidea gene, Ppargc1a gene) [nucleoplasm] 5 × [CandidateSet:R-ALL-9844666] PPARG natural ligands [nucleoplasm] 5 × [DefinedSet:R-MMU-9854718] Pparg:Rxra [nucleoplasm] 5 × [CandidateSet:R-ALL-9844664] RXRA natural ligands [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9844612] EBF2 determines and maintains brown adipocyte identity [LiteratureReference:9844685] Early B Cell Factor Activity Controls Developmental and Adaptive Thermogenic Gene Programming in Adipocytes [LiteratureReference:9844640] Loss of TLE3 promotes the mitochondrial program in beige adipocytes and improves glucose metabolism [LiteratureReference:9844687] BAF60a deficiency uncouples chromatin accessibility and cold sensitivity from white fat browning [LiteratureReference:9828141] MLL3/MLL4 are required for CBP/p300 binding on enhancers and super-enhancer formation in brown adipogenesis [LiteratureReference:9844565] Comparative Transcriptomic and Epigenomic Analyses Reveal New Regulators of Murine Brown Adipogenesis
maxDepth	1
modified	[InstanceEdit:9855222] Orlic-Milacic, Marija, 2023-11-29
name	Pparg binds Ebf2-bound gene loci
orthologousEvent	[BlackBoxEvent:R-HSA-9844440] PPARG binds EBF2-bound gene loci - Homo sapiens
output	[CandidateSet:R-MMU-9854714] Ebf2, Ebf2:Blnc1 lncRNA:Hnrnpu:Activated Pparg:Rxra:Ppara gene, Prdm16 gene, Ucp1 gene, (Cidea gene, Ppargc1a gene) [nucleoplasm]
releaseDate	2024-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9854531] Chun, Tae-Hwa, 2023-11-29
schemaClass	BlackBoxEvent
species	[Species:48892] Mus musculus
stId	R-MMU-9844700
summation	[Summation:9844690] In mouse beige and brown adipocyte lineages binding of Ebf2 ...