Pparg binds Ebf2-bound gene loci

Stable Identifier
R-MMU-9844700
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Pparg binds Ebf2-bound gene loci
In mouse beige and brown adipocyte lineages binding of Ebf2 transcription factor to Ebf sites within regulatory sequences of genes involved in brown/beige adipogenesis facilitates recruitment of Pparg to the nearby PPREs (peroxisome proliferator response elements). PPARG enhances EBF2-stimulated transcription of the brown/beige adipogenesis target genes: Ppara, Prdm16, and Ucp1 by directly binding to these gene loci (Rajakumari et al. 2013). Pparg binding to the Ucp1 gene locus was also reported in Angueira et al. 2020, and Liu et al. 2020. Pparg also binds to the Ebf2 target gene Ppargc1a (Pearson et al. 2019), which encodes brown/beige fat tissue-specific coactivator of Pparg, Pgc1alpha, but Pparg-mediated induction of Ppargc1a gene expression has not been tested. PPARG also binds to the regulatory region of the Cidea gene (Brunmeir et al. 2016), a candidate Ebf2 target, but Pparg-mediated induction of Cidea has not been tested. Ppargc1a and Cidea genes are annotated as candidate targets of Pparg in the context of prior Ebf2-mediated regulation of brown/beige adipogenesis genes.
Literature References
PubMed ID Title Journal Year
32130892 Early B Cell Factor Activity Controls Developmental and Adaptive Thermogenic Gene Programming in Adipocytes

Angueira, AR, Shapira, SN, Ishibashi, J, Sampat, S, Sostre-Colón, J, Emmett, MJ, Titchenell, PM, Lazar, MA, Lim, HW, Seale, P

Cell Rep 2020
32404872 BAF60a deficiency uncouples chromatin accessibility and cold sensitivity from white fat browning

Liu, T, Mi, L, Xiong, J, Orchard, P, Yu, Q, Yu, L, Zhao, XY, Meng, ZX, Parker, SCJ, Lin, JD, Li, S

Nat Commun 2020
28398509 MLL3/MLL4 are required for CBP/p300 binding on enhancers and super-enhancer formation in brown adipogenesis

Lai, B, Lee, JE, Jang, Y, Wang, L, Peng, W, Ge, K

Nucleic Acids Res 2017
31123067 Loss of TLE3 promotes the mitochondrial program in beige adipocytes and improves glucose metabolism

Pearson, S, Loft, A, Rajbhandari, P, Simcox, J, Lee, S, Tontonoz, P, Mandrup, S, Villanueva, CJ

Genes Dev 2019
27923061 Comparative Transcriptomic and Epigenomic Analyses Reveal New Regulators of Murine Brown Adipogenesis

Brunmeir, R, Wu, J, Peng, X, Kim, SY, Julien, SG, Zhang, Q, Xie, W, Xu, F

PLoS Genet 2016
23499423 EBF2 determines and maintains brown adipocyte identity

Rajakumari, S, Wu, J, Ishibashi, J, Lim, HW, Giang, AH, Won, KJ, Reed, RR, Seale, P

Cell Metab 2013
Participants
Input
Output
Orthologous Events
PPARG binds EBF2-bound gene loci (Homo sapiens)
Authored
Orlic-Milacic, M  (2023-09-25)
Reviewed
Chun, TH  (2023-11-29)
Created
Orlic-Milacic, M  (2023-09-21)
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