Reactome | Factors involved in megakaryocyte development and platelet production

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Factors involved in megakaryocyte development and platelet production Show undefined attributes

created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10100561
displayName	Factors involved in megakaryocyte development and platelet production
eventOf	[TopLevelPathway:R-MMU-109582] Hemostasis - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-MMU-983285] RAD51B binds RAD51C - Mus musculus [Reaction:R-MMU-983218] RAD51B:RAD51C binds single-stranded DNA - Mus musculus [Reaction:R-MMU-992708] Dual-specific AKAPs bind type I and II PKA regulatory subunits - Mus musculus [Reaction:R-MMU-992703] Mitofusins trans-interact linking mitochondria prior to fusion - Mus musculus [Reaction:R-MMU-994106] HP1 alpha binds Histone H3K9(me)3 - Mus musculus [Reaction:R-MMU-994137] ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 - Mus musculus [Reaction:R-MMU-994140] ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4 - Mus musculus [Reaction:R-MMU-2267372] ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 - Mus musculus [Reaction:R-MMU-996727] REST recruits the BHC complex - Mus musculus [Reaction:R-MMU-996755] ZFPM proteins bind GATA proteins - Mus musculus [Reaction:R-MMU-997263] JMJD1C demethylates H3K9 mono- and di-methylation - Mus musculus [Reaction:R-MMU-997237] SH2B proteins bind JAK2 - Mus musculus [Reaction:R-MMU-1008248] Adenylate Kinase 3 is a GTP-AMP phosphotransferase - Mus musculus [Reaction:R-MMU-1008200] NFE2 binds the beta globin locus control region - Mus musculus [Reaction:R-MMU-1011576] EHD proteins interact with Rabenosyn-5 - Mus musculus [Reaction:R-MMU-1011600] Rabenosyn-5 connects Rab5 to VPS-45 - Mus musculus [Reaction:R-MMU-1011598] DOCKs bind to RhoGEFs - Mus musculus [Pathway:R-MMU-983189] Kinesins - Mus musculus
inferredFrom	[Pathway:R-HSA-983231] Factors involved in megakaryocyte development and platelet production - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	Factors involved in megakaryocyte development and platelet production
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-983231
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[TopLevelPathway:R-MMU-109582] Hemostasis
(inferredTo)	[Pathway:R-HSA-983231] Factors involved in megakaryocyte development and platelet production

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