Reactome | Expression of Grem1 in metanephric mesenchyme

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Expression of Grem1 in metanephric mesenchyme Show undefined attributes

authored	[InstanceEdit:9831002] May, Bruce, 2023-03-17
category	omitted
compartment	[Compartment:7660] nucleoplasm [Compartment:984] extracellular region
created	[InstanceEdit:9831050] May, Bruce, 2023-03-17
dbId	9831007
displayName	Expression of Grem1 in metanephric mesenchyme
edited	[InstanceEdit:9831002] May, Bruce, 2023-03-17
input	[EntityWithAccessionedSequence:R-MMU-9831036] Grem1 gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9831850] Six1 regulates Grem1 expression in the metanephric mesenchyme to initiate branching morphogenesis [LiteratureReference:9831880] Gremlin-mediated BMP antagonism induces the epithelial-mesenchymal feedback signaling controlling metanephric kidney and limb organogenesis [LiteratureReference:9831892] Reduction of BMP4 activity by gremlin 1 enables ureteric bud outgrowth and GDNF/WNT11 feedback signalling during kidney branching morphogenesis
maxDepth	1
modified	[InstanceEdit:9851767] May, Bruce, 2023-10-31
name	Expression of Grem1 in metanephric mesenchyme
orthologousEvent	[BlackBoxEvent:R-HSA-9831017] Expression of GREM1 in metanephric mesenchyme - Homo sapiens
output	[EntityWithAccessionedSequence:R-MMU-9831046] Grem1 [extracellular region]
regulatedBy	[PositiveGeneExpressionRegulation:9831041] Positive gene expression regulation by 'Six1 [nucleoplasm]'
regulationReference	[RegulationReference:9831861] Positive gene expression regulation by 'Six1 [nucleoplasm]' Six1 regulates Grem1 expression in the metanephric mesenchyme to initiate branching morphogenesis
releaseDate	2023-12-06
reviewStatus	[ReviewStatus:9821383] three stars
schemaClass	BlackBoxEvent
species	[Species:48892] Mus musculus
stId	R-MMU-9831007
summation	[Summation:9831853] Gremlin 1 (Grem1), a secreted BMP antagonist, is expressed i...

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