Gremlin 1 (Grem1), a secreted BMP antagonist, is expressed i...

created [InstanceEdit:9831870] May, Bruce, 2023-03-25
dbId 9831853
displayName Gremlin 1 (Grem1), a secreted BMP antagonist, is expressed i...
modified [InstanceEdit:9832759] May, Bruce, 2023-04-06
schemaClass Summation
text Gremlin 1 (Grem1), a secreted BMP antagonist, is expressed in the metanephric mesenchyme (Michos et al. 2004, Michos et al. 2007). Expression of Grem1 in the metanephric mesenchyme is dependent on Six1 (Nie et al. 2011). Absence of Grem1 causes disrupted ureter growth and branching (Michos et al. 2004) due to excessive Bmp4 signaling via phospho-Smad proteins (Michos et al. 2007).
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