Reactome | Hira and Npm2 assemble H3.3-containing nucleosomes on paternal DNA

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Hira and Npm2 assemble H3.3-containing nucleosomes on paternal DNA Show undefined attributes

authored	[InstanceEdit:9822139] May, Bruce, 2022-12-19
catalystActivity	[CatalystActivity:9822191] histone chaperone activity of Hira:Npm2:dsDNA [nucleoplasm]
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9822197] May, Bruce, 2022-12-21
dbId	9822208
displayName	Hira and Npm2 assemble H3.3-containing nucleosomes on paternal DNA
edited	[InstanceEdit:9822139] May, Bruce, 2022-12-19
input	[EntityWithAccessionedSequence:R-MMU-9822227] H1.8 [nucleoplasm] 2 × [EntityWithAccessionedSequence:R-MMU-9822584] H3R17me2a [nucleoplasm] [Complex:R-MMU-9822104] Hira:Npm2:dsDNA [nucleoplasm] 2 × [EntityWithAccessionedSequence:R-MMU-573313] Histone H2A.x [nucleoplasm] 2 × [CandidateSet:R-MMU-573339] Histone H2B [nucleoplasm] 2 × [EntityWithAccessionedSequence:R-MMU-573379] Histone H4 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9821954] Initiation of Parental Genome Reprogramming in Fertilized Oocyte by Splicing Kinase SRPK1-Catalyzed Protamine Phosphorylation [LiteratureReference:9822214] Rapid H1 linker histone transitions following fertilization or somatic cell nuclear transfer: evidence for a uniform developmental program in mice [LiteratureReference:9822209] Linker histone H1FOO regulates the chromatin structure in mouse zygotes [LiteratureReference:9822204] Hira-mediated H3.3 incorporation is required for DNA replication and ribosomal RNA transcription in the mouse zygote [LiteratureReference:9822220] Changes in the nuclear deposition of histone H2A variants during pre-implantation development in mice [LiteratureReference:9822259] Histone variant H3.3-mediated chromatin remodeling is essential for paternal genome activation in mouse preimplantation embryos [LiteratureReference:9822260] Histone variant H3.3 is an essential maternal factor for oocyte reprogramming
maxDepth	1
modified	[InstanceEdit:9841067] May, Bruce, 2023-08-08
name	Hira and Npm2 assemble H3.3-containing nucleosomes on paternal DNA
orthologousEvent	[BlackBoxEvent:R-HSA-9822185] HIRA and NPM2 assemble H3.3-containing nucleosomes on paternal DNA - Homo sapiens
output	[Complex:R-MMU-9822183] H3.3, H2ax chromatin:H1.8 [nucleoplasm] [EntityWithAccessionedSequence:R-MMU-9822123] Hira [nucleoplasm] [EntityWithAccessionedSequence:R-MMU-9821978] Npm2 [nucleoplasm]
releaseDate	2023-09-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9841065] Xie, Wei, 2023-08-08
schemaClass	BlackBoxEvent
species	[Species:48892] Mus musculus
stId	R-MMU-9822208
summation	[Summation:9822236] Hira mediates incorporation of the histone H3 variant H3.3 i...