Reactome | Csf1 dimer:p-Y559-Csf1r dimer:Fyn,Hck,Src,Yes1 binds Cbl

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Csf1 dimer:p-Y559-Csf1r dimer:Fyn,Hck,Src,Yes1 binds Cbl Show undefined attributes

authored	[InstanceEdit:9817996] Stanley, E Richard, 2022-10-06
category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9817989] May, Bruce, 2022-10-08
dbId	9817994
displayName	Csf1 dimer:p-Y559-Csf1r dimer:Fyn,Hck,Src,Yes1 binds Cbl
edited	[InstanceEdit:9819299] May, Bruce, 2022-11-02
input	[EntityWithAccessionedSequence:R-MMU-9680636] Cbl [cytosol] [Complex:R-MMU-9817993] Csf1 dimer:p-Y559-Csf1r dimer:Fyn,Hck,Src,Yes1 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9680735] CSF-1 stimulated multiubiquitination of the CSF-1 receptor and of Cbl follows their tyrosine phosphorylation and association with other signaling proteins [LiteratureReference:9763951] c-Cbl is transiently tyrosine-phosphorylated, ubiquitinated, and membrane-targeted following CSF-1 stimulation of macrophages [LiteratureReference:9681133] A juxtamembrane tyrosine in the colony stimulating factor-1 receptor regulates ligand-induced Src association, receptor kinase function, and down-regulation
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Csf1 dimer:p-Y559-Csf1r dimer:Fyn,Hck,Src,Yes1 binds Cbl
orthologousEvent	[Reaction:R-HSA-9817983] CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK binds CBL - Homo sapiens
output	[Complex:R-MMU-9763898] Csf1 dimer:p-Y-559-Csf1r:Fyn,Hck,Src,Yes1:Cbl [plasma membrane]
releaseDate	2022-12-07
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-9817994
summation	[Summation:9818008] Cbl associates with the phosphorylated Csf1r (Wang et al. 19...

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