Reactome | LRP2-mediated TCN2:RCbl uptake and delivery to lysosome

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LRP2-mediated TCN2:RCbl uptake and delivery to lysosome Show undefined attributes

catalystActivity	[CatalystActivity:10092193] cargo receptor activity of LRP2:LDLRAP1:TCN2:RCbl [plasma membrane]
category	omitted
compartment	[Compartment:161320] lysosomal lumen [Compartment:876] plasma membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10092195
displayName	LRP2-mediated TCN2:RCbl uptake and delivery to lysosome
eventOf	[Pathway:R-MMU-9758890] Transport of RCbl within the body - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[BlackBoxEvent:R-HSA-9759202] LRP2-mediated TCN2:RCbl uptake and delivery to lysosome - Homo sapiens
input	[Complex:R-MMU-9759208] LRP2:LDLRAP1:TCN2:RCbl [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	LRP2-mediated TCN2:RCbl uptake and delivery to lysosome
output	[Complex:R-MMU-9759635] LRP2:LDLRAP1 [plasma membrane] [Complex:R-MMU-3000242] TCN2:RCbl [lysosomal lumen]
precedingEvent	[Reaction:R-MMU-9759209] LRP2 binds extracellular TCN2:RCbl - Mus musculus
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:48892] Mus musculus
stId	R-MMU-9759202
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-9758890] Transport of RCbl within the body
(inferredTo)	[BlackBoxEvent:R-HSA-9759202] LRP2-mediated TCN2:RCbl uptake and delivery to lysosome

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