Reactome | Csf1r-associated Sos1 mediates exchange of GTP for GDP bound to Ras

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Csf1r-associated Sos1 mediates exchange of GTP for GDP bound to Ras Show undefined attributes

authored	[InstanceEdit:9682195] May, Bruce, 2020-04-08
catalystActivity	[CatalystActivity:9682577] guanyl-nucleotide exchange factor activity of Csf1 dimer:p-Y559-Csf1r dimer:Grb2:Sos1 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9682571] May, Bruce, 2020-04-11
dbId	9682572
displayName	Csf1r-associated Sos1 mediates exchange of GTP for GDP bound to Ras
edited	[InstanceEdit:9682195] May, Bruce, 2020-04-08
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-MMU-9682581] Kras:GDP [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9682584] Ras-dependent and -independent pathways target the mitogen-activated protein kinase network in macrophages [LiteratureReference:9681709] Both src-dependent and -independent mechanisms mediate phosphatidylinositol 3-kinase regulation of colony-stimulating factor 1-activated mitogen-activated protein kinases in myeloid progenitors [LiteratureReference:9682764] Macrophage proliferation is regulated through CSF-1 receptor tyrosines 544, 559, and 807
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Csf1r-associated Sos1 mediates exchange of GTP for GDP bound to Ras
orthologousEvent	[Reaction:R-HSA-9680385] CSF1R-associated SOS1 mediates exchange of GTP for GDP bound to RAS - Homo sapiens
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-MMU-9682582] Kras:GTP [plasma membrane]
releaseDate	2022-12-07
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9817996] Stanley, E Richard, 2022-10-06
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-9682572
summation	[Summation:9682580] In response to the activation of Csf1r by Csf1, Sos1 bound t...

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