Reactome | p-Y-Jak1,2 phosphorylates Stat1,3,5 in Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1:p-Jak2:p-Tyk2:Stat1,3,5

Schema > Reaction > Entries

p-Y-Jak1,2 phosphorylates Stat1,3,5 in Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1:p-Jak2:p-Tyk2:Stat1,3,5 Show undefined attributes

authored	[InstanceEdit:9674838] May, Bruce, 2020-01-27
catalystActivity	[CatalystActivity:9677134] protein tyrosine kinase activity of Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2:Stat1,3,5 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9674890] May, Bruce, 2020-01-29
dbId	9674908
displayName	p-Y-Jak1,2 phosphorylates Stat1,3,5 in Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1:p-Jak2:p-Tyk2:Stat1,3,5
edited	[InstanceEdit:9674838] May, Bruce, 2020-01-27
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-MMU-9674981] Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2:Stat1,3,5 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9674904] Tyrosine residues in the granulocyte colony-stimulating factor (G-CSF) receptor mediate G-CSF-induced differentiation of murine myeloid leukemic (M1) cells [LiteratureReference:9674891] The membrane-distal cytoplasmic region of human granulocyte colony-stimulating factor receptor is required for STAT3 but not STAT1 homodimer formation [LiteratureReference:9674953] STAT3-mediated differentiation and survival and of myeloid cells in response to granulocyte colony-stimulating factor: role for the cyclin-dependent kinase inhibitor p27(Kip1) [LiteratureReference:9674906] Multiple signals mediate proliferation, differentiation, and survival from the granulocyte colony-stimulating factor receptor in myeloid 32D cells [LiteratureReference:9674963] Identification of a novel Stat3 recruitment and activation motif within the granulocyte colony-stimulating factor receptor [LiteratureReference:9676040] Distinct regions of the granulocyte colony-stimulating factor receptor are required for tyrosine phosphorylation of the signaling molecules JAK2, Stat3, and p42, p44MAPK [LiteratureReference:9676049] Multiple pathways contribute to the hyperproliferative responses from truncated granulocyte colony-stimulating factor receptors [LiteratureReference:9674969] Jak1 plays an essential role for receptor phosphorylation and Stat activation in response to granulocyte colony-stimulating factor [LiteratureReference:9707885] Stimulation of Stat5 by granulocyte colony-stimulating factor (G-CSF) is modulated by two distinct cytoplasmic regions of the G-CSF receptor
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	p-Y-Jak1,2 phosphorylates Stat1,3,5 in Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1:p-Jak2:p-Tyk2:Stat1,3,5
orthologousEvent	[Reaction:R-HSA-9674567] p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2 - Homo sapiens
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-MMU-9674939] Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2:p-Y-Stat1,3,5 [plasma membrane]
releaseDate	2021-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9709304] Touw, Ivo P, 2020-12-12
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-9674908
summation	[Summation:9677135] Phosphorylated Jak1 (p-Y-Jak1) phosphorylates the Stat prote...