Reactome | p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2

Schema > Reaction > Entries

p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2 Show undefined attributes

authored	[InstanceEdit:9674579] May, Bruce, 2020-01-13
catalystActivity	[CatalystActivity:9674574] protein tyrosine kinase activity of CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:STAT1,3,5 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9674559] May, Bruce, 2020-01-15
dbId	9674567
displayName	p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2
edited	[InstanceEdit:9674579] May, Bruce, 2020-01-13
eventOf	[Pathway:R-HSA-9674555] Signaling by CSF3 (G-CSF) - Homo sapiens
followingEvent	[Reaction:R-HSA-9674563] CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5 - Homo sapiens
inferredFrom	[Reaction:R-MMU-9674908] p-Y-Jak1,2 phosphorylates Stat1,3,5 in Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1:p-Jak2:p-Tyk2:Stat1,3,5 - Mus musculus
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-9674553] CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:STAT1,3,5 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:9674949] Multiple signaling pathways induced by granulocyte colony-stimulating factor involving activation of JAKs, STAT5, and/or STAT3 are required for regulation of three distinct classes of immediate early genes [LiteratureReference:9674893] Rapid activation of the STAT3 transcription factor by granulocyte colony-stimulating factor [LiteratureReference:9674947] The granulocyte colony stimulating factor (G-CSF) activates Jak/STAT and MAPK pathways in a trophoblastic cell line [LiteratureReference:9674885] Tyrosine-dependent and -independent mechanisms of STAT3 activation by the human granulocyte colony-stimulating factor (G-CSF) receptor are differentially utilized depending on G-CSF concentration [LiteratureReference:9676036] Granulocyte colony-stimulating factor receptor signalling via Janus kinase 2/signal transducer and activator of transcription 3 in ovarian cancer [LiteratureReference:9674969] Jak1 plays an essential role for receptor phosphorylation and Stat activation in response to granulocyte colony-stimulating factor
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-9674551] CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 [plasma membrane]
precedingEvent	[Reaction:R-HSA-9674562] CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5 - Homo sapiens
regulatedBy	[NegativeRegulation:9707970] Negative regulation by 'SOCS1,3:p-4Y-CSF3R:CSF3dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 [plasma membrane]'
regulationReference	[RegulationReference:9707973] Negative regulation by 'SOCS1,3:p-4Y-CSF3R:CSF3dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 [plasma membrane]' Suppression of cytokine signaling by SOCS3: characterization of the mode of inhibition and the basis of its specificity
releaseDate	2021-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9709304] Touw, Ivo P, 2020-12-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9674567
summation	[Summation:9677147] Phosphorylated JAK1 (p-Y-JAK1) phosphorylates the STAT prote...

Referrals

(hasEvent)	[Pathway:R-HSA-9674555] Signaling by CSF3 (G-CSF)
(precedingEvent)	[Reaction:R-HSA-9674563] CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5
(inferredTo)	[Reaction:R-MMU-9674908] p-Y-Jak1,2 phosphorylates Stat1,3,5 in Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1:p-Jak2:p-Tyk2:Stat1,3,5