Reactome | phospho-Shc1 [cytosol]

Schema > EntityWithAccessionedSequence > Entries

candidateOf	[CandidateSet:R-MMU-9842591] p-3Y SHC1-1,SHC1-2,SHC1-3 [cytosol] - Mus musculus
compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-MMU-912313] IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] - Mus musculus
consumedByEvent	[Reaction:R-MMU-8934446] Activated PKC phosphorylates SHC1 - Mus musculus [Reaction:R-MMU-5686073] GRB2-1:SOS1 binds p-3Y-SHC1 - Mus musculus
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10019235
displayName	phospho-Shc1 [cytosol]
endCoordinate	583
hasModifiedResidue	[ModifiedResidue:9989255] O4'-phospho-L-tyrosine at 427 (in Homo sapiens) [ModifiedResidue:9999755] O4'-phospho-L-tyrosine at 349 (in Homo sapiens) [ModifiedResidue:9999756] O4'-phospho-L-tyrosine at 350 (in Homo sapiens)
inDisease	false
inferredFrom	[DefinedSet:R-HSA-2404184] p-3Y-SHC1 [cytosol] - Homo sapiens [DefinedSet:R-HSA-8934443] p-3Y-SHC1-1,p-3Y-SHC1-2 [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2404176] p-Y349,Y350,Y427-SHC1-1 [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-912321] p-Y349,Y350,Y427-SHC1 [cytosol] - Homo sapiens
maxDepth	1
name	phospho-Shc1 p-Y349,Y350,Y427-SHC1 P98083
producedByEvent	[Reaction:R-MMU-5686072] p-3Y-SHC1 dissociates from IGF1R - Mus musculus
referenceEntity	[ReferenceGeneProduct:uniprot:P98083] UniProt:P98083 Shc1
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48892] Mus musculus
stId	R-MMU-912321
startCoordinate	1

(hasCandidate)	[CandidateSet:R-MMU-9842591] p-3Y SHC1-1,SHC1-2,SHC1-3 [cytosol]
(hasComponent)	[Complex:R-MMU-912313] IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] [Complex:R-MMU-5686070] GRB2-1:SOS1:p-3Y-SHC1 [cytosol] [Complex:R-MMU-2404190] IGF1,2:p-3Y-IGF1R:p-3Y-SHC1 [plasma membrane] [Complex:R-MMU-8854980] 2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] [Complex:R-MMU-913366] High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] [Complex:R-MMU-913428] High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] [Complex:R-MMU-913412] IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane]
(input)	[Reaction:R-MMU-5686073] GRB2-1:SOS1 binds p-3Y-SHC1 [Reaction:R-MMU-8934446] Activated PKC phosphorylates SHC1
(output)	[Reaction:R-MMU-5686072] p-3Y-SHC1 dissociates from IGF1R
(inferredTo)	[DefinedSet:R-HSA-2404184] p-3Y-SHC1 [cytosol] [DefinedSet:R-HSA-8934443] p-3Y-SHC1-1,p-3Y-SHC1-2 [cytosol] [EntityWithAccessionedSequence:R-HSA-2404176] p-Y349,Y350,Y427-SHC1-1 [cytosol] [EntityWithAccessionedSequence:R-HSA-912321] p-Y349,Y350,Y427-SHC1 [cytosol]