Reactome | ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA

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ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA Show undefined attributes

catalystActivity	[CatalystActivity:10086669] arachidonate 15-lipoxygenase activity of ALOX15 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10086691
displayName	ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA
eventOf	[Pathway:R-MMU-9018681] Biosynthesis of protectins - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-9020257] LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1 - Mus musculus
inferredFrom	[Reaction:R-HSA-9020262] ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA - Homo sapiens
input	[SimpleEntity:R-ALL-9024522] 17(R)-Hp-DHA [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA
output	[SimpleEntity:R-ALL-9024893] 17R(16)-epoxy-DHA [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol]
precedingEvent	[Reaction:R-MMU-9020261] Ac-PTGS2 dimer oxidises DHA to 17(R)-Hp-DHA - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-9020262
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-9018681] Biosynthesis of protectins
(precedingEvent)	[Reaction:R-MMU-9020257] LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1
(inferredTo)	[Reaction:R-HSA-9020262] ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA

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