Reactome | Ac-PTGS2 dimer oxidises DHA to 17(R)-Hp-DHA

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Ac-PTGS2 dimer oxidises DHA to 17(R)-Hp-DHA Show undefined attributes

catalystActivity	[CatalystActivity:10042754] oxidoreductase activity, acting on single donors with incorporation of molecular oxygen of Ac-PTGS2 dimer [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10086689
displayName	Ac-PTGS2 dimer oxidises DHA to 17(R)-Hp-DHA
eventOf	[Pathway:R-MMU-9018677] Biosynthesis of DHA-derived SPMs - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-9020262] ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA - Mus musculus [Reaction:R-MMU-9020271] GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA - Mus musculus
inferredFrom	[Reaction:R-HSA-9020261] Ac-PTGS2 dimer oxidises DHA to 17(R)-Hp-DHA - Homo sapiens
input	[SimpleEntity:R-ALL-9024011] DHA [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Ac-PTGS2 dimer oxidises DHA to 17(R)-Hp-DHA
output	[SimpleEntity:R-ALL-9024522] 17(R)-Hp-DHA [cytosol]
precedingEvent	[Reaction:R-MMU-2314686] ASA- acetylates PTGS2 - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-9020261
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-9018677] Biosynthesis of DHA-derived SPMs
(precedingEvent)	[Reaction:R-MMU-9020262] ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA [Reaction:R-MMU-9020271] GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA
(inferredTo)	[Reaction:R-HSA-9020261] Ac-PTGS2 dimer oxidises DHA to 17(R)-Hp-DHA

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