Reactome | Ptcra gene expression is positively stimulated by Notch3 and inhibited by Ik1

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Ptcra gene expression is positively stimulated by Notch3 and inhibited by Ik1 Show undefined attributes

authored	[InstanceEdit:9021699] Orlic-Milacic, Marija, 2017-09-20
category	omitted
compartment	[Compartment:7660] nucleoplasm [Compartment:876] plasma membrane
created	[InstanceEdit:9016862] Orlic-Milacic, Marija, 2017-08-16
dbId	9016859
displayName	Ptcra gene expression is positively stimulated by Notch3 and inhibited by Ik1
edited	[InstanceEdit:9027527] Orlic-Milacic, Marija, 2017-11-02
input	[EntityWithAccessionedSequence:R-MMU-9016890] Ptcra gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9015723] Pre-TCR-triggered ERK signalling-dependent downregulation of E2A activity in Notch3-induced T-cell lymphoma [LiteratureReference:9016860] Notch3 and the Notch3-upregulated RNA-binding protein HuD regulate Ikaros alternative splicing
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Ptcra gene expression is positively stimulated by Notch3 and inhibited by Ik1
orthologousEvent	[BlackBoxEvent:R-HSA-9016861] PTCRA gene expression is stimulated by NOTCH3 and inhibited by IK1 - Homo sapiens
output	[EntityWithAccessionedSequence:R-MMU-9016887] Ptcra [plasma membrane]
regulatedBy	[PositiveRegulation:R-MMU-9016898] Positive regulation by 'Notch3 coactivator complex [nucleoplasm]' [NegativeGeneExpressionRegulation:R-MMU-9017135] Negative gene expression regulation by 'Ik1:Ptcra gene [nucleoplasm]'
regulationReference	[RegulationReference:9641389] Negative gene expression regulation by 'Ik1:Ptcra gene [nucleoplasm]' Notch3 and the Notch3-upregulated RNA-binding protein HuD regulate Ikaros alternative splicing [RegulationReference:9642464] Positive regulation by 'Notch3 coactivator complex [nucleoplasm]' Pre-TCR-triggered ERK signalling-dependent downregulation of E2A activity in Notch3-induced T-cell lymphoma
releaseDate	2017-12-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9027525] Haw, Robin, 2017-10-30
schemaClass	BlackBoxEvent
species	[Species:48892] Mus musculus
stId	R-MMU-9016859
summation	[Summation:9016904] Mouse Notch3 intracellular domain, NICD3, induces transcript...

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